Robert T Mcdevitt

US Patent:

6340670, Jan 22, 2002

Filed:

Nov 22, 1999

Appl. No.:

09/447009

Inventors:

Scott C. Mayer - Robbinsville NJ
Paul J. Dollings - Newtown PA
Robert E. McDevitt - Somerset NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31702

US Classification:

514 25, 514 53, 536 41, 536 172, 53612313

Abstract:

This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure with the variables defined herein.

US Patent:

6369072, Apr 9, 2002

Filed:

Mar 2, 2001

Appl. No.:

09/798088

Inventors:

Michael S. Malamas - Jamison PA
Robert E. McDevitt - Somerset NJ
Folake O. Adebayo - Cranbury NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31437

US Classification:

514301, 514302, 514303, 546114, 546116, 546118

Abstract:

This invention provides substituted compounds of the general formulae: wherein B and E are C or N; D, G and W are O, S, or N; or salt forms thereof, and methods and pharmaceutical compositions for their use in treating disorders related to insulin resistance or hyperglycemia.

US Patent:

6391897, May 21, 2002

Filed:

Mar 2, 2001

Appl. No.:

09/798109

Inventors:

Michael S. Malamas - Jamison PA
Robert E. McDevitt - Somerset NJ
Folake O. Adebayo - Cranbury NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31381

US Classification:

514340, 514443, 514469, 5462684, 549 59

Abstract:

This invention provides substituted compounds of the general formulae: wherein B and E are C or N; D, G and W are O, S, or N; or salt forms thereof, and methods and pharmaceutical compositions for their use in treating disorders related to insulin resistance or hyperglycemia.

US Patent:

6451845, Sep 17, 2002

Filed:

Apr 23, 2001

Appl. No.:

09/887672

Inventors:

Paul J. Dollings - Newtown PA
Robert E. McDevitt - Somerset NJ
Folake O. Adebayo - Cranbury NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31381

US Classification:

514444, 514336, 514449, 514361, 5462817, 5462834, 549429, 549472, 549 6, 5483561, 5483611

Abstract:

This invention provides compounds of Formula I having the structure wherein R and R are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl substituted with trifluoromethyl, chloro, methoxy, or trifluoromethoxy; R and R are each, independently, hydrogen, carboxyl, hydroxyl, hydoxyalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, alkanoyloxy of 2-7 carbon atoms, perfluoroalkanoyloxy of 2-7 carbon atoms, arylalkoxy of 7-15 carbon atoms, aryloxy of 6-12 carbon atoms, aroyloxy of 6-12 carbon atoms, aryloxycarbonyl of 7-13 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, tetrazolyl, mercapto, nitrile, nitro, amino, âNHSO CF , carbamoyl, carboxyaldehyde, halogen, acylamino, 3-hydroxy-cyclobut-3-ene-4-yl-1,2-dione, pyridyl, isoxazolyl, pyrimidyl or pyrimidyl substituted with mercapto, or tetronic acid; R is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, naphthalenylmethyl, benzyl or benzyl substituted with halogen, R and R are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or perfluoroalkyl of 1-6 carbon atoms, or R and R may be taken together as a diene unit having the structure âCH CHâCH CHâ; W is S or O, X is âNR CH â, âNR â, or O; R is hydrogen or alkyl; Y is carbonyl, methylene, ethyl, or âNHCH â; Z is phenyl, pyridyl, naphthyl, thienyl, furyl, pyrrolyl, pyrazolyl, isoxazolyl, or isothiazolyl; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

US Patent:

6683107, Jan 27, 2004

Filed:

Aug 8, 2002

Appl. No.:

10/215311

Inventors:

Paul J. Dollings - Newtown PA
Robert E. McDevitt - Somerset NJ
Folake O. Adebayo - Cranbury NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31381

US Classification:

514438, 514461, 514465, 549 29, 549429

Abstract:

This invention provides compounds of Formula I having the structure wherein R and R are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl substituted with trifluoromethyl, chloro, methoxy, or trifluoromethoxy; R and R are each, independently, hydrogen, carboxyl, hydroxyl, hydoxyalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, alkanoyloxy of 2-7 carbon atoms, perfluoroalkanoyloxy of 2-7 carbon atoms, arylalkoxy of 7-15 carbon atoms, aryloxy of 6-12 carbon atoms, aroyloxy of 6-12 carbon atoms, aryloxycarbonyl of 7-13 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkylamino of 1-6 carbon atoms, dialkylamnino of 1-6 carbon atoms per alkyl group, tetrazolyl, mercapto, nitrile, nitro, amino, âNHSO CF , carbamoyl, carboxyaldehyde, halogen, acylamino, 3-hydroxy-cyclobut-3-ene-4-yl-1,2-dione, pyridyl, isoxazolyl, pyrimidyl or pyrimidyl substituted with mercapto, or tetronic acid; R is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, naphthalenylmethyl, benzyl or benzyl substituted with halogen, R and R are each, independently, hydrogen, alkyl of 1-6 carbon atoms, or perfluoroalkyl of 1-6 carbon atoms, or R and R may be taken together as a diene unit having the structure âCH CHâCH CHâ; W is S or O, X is âNR CH â, âNR â, or O; R is hydrogen or alkyl; Y is carbonyl, methylene, ethyl, or âNHCH â; Z is phenyl, pyridyl, naphthyl, thienyl, furyl, pyrrolyl, pyrazolyl, isoxazolyl, or isothiazolyl; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

US Patent:

6794403, Sep 21, 2004

Filed:

Dec 4, 2002

Appl. No.:

10/309699

Inventors:

Michael S. Malamas - Jamison PA
Robert E. McDevitt - Somerset NJ
Iwan Gunawan - Somerset NJ
Eric S. Manas - Lafayette Hill PA
Michael D. Collini - Clifton Heights PA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31423

US Classification:

514375, 548224

Abstract:

This invention provides estrogen receptor modulators of formula I, having the structure wherein R , R , R , R , R , and R , and X as defined in the specification, or a pharmaceutically acceptable salt thereof.

US Patent:

7071185, Jul 4, 2006

Filed:

Apr 24, 2003

Appl. No.:

10/422592

Inventors:

P. Sivaramakrishnan Ramamoorthy - Plainsboro NJ, US
Robert E. McDevitt - Somerset NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61P 25/00
A61K 31/55
C07D 243/00

US Classification:

514219, 540555

Abstract:

Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided:.

US Patent:

7129258, Oct 31, 2006

Filed:

Aug 19, 2004

Appl. No.:

10/921409

Inventors:

Michael S. Malamas - Jamison PA, US
Robert E. McDevitt - Somerset NJ, US
Iwan Gunawan - Somerset NJ, US
Eric S. Manas - Lafayette Hill PA, US
Michael D. Collini - Clifton Heights PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/425
C07D 277/62

US Classification:

514367, 514394, 548178, 5483101

Abstract:

This invention provides estrogen receptor modulators of formula I, having the structure.