Robert James Mckenzie

US Patent:

6649922, Nov 18, 2003

Filed:

Oct 29, 2002

Appl. No.:

10/281506

Inventors:

Robert McKenzie - Tampa FL 33615

International Classification:

G21F 500

US Classification:

2505061, 2505051, 2505151

Abstract:

A shielded packaging system is formed by a top panel and a bottom panel that are connected to one another along a preselected extent of their respective peripheral edges. An opening is formed along the unconnected extent and provides access to the space between the panels that holds radioactive items. Each panel includes at least two layers of lead foil so that if a pinhole is formed in either layer, the probability of two pinholes lining up and enabling radiation to escape from the space is minimal. The layers of lead foil have at least one ridge formed in them at their respective peripheral edges so that radiation traveling in a straight path parallel to the top and bottom panels encounters the ridges and cannot escape through the edges of the package.

US Patent:

6932758, Aug 23, 2005

Filed:

Feb 12, 2003

Appl. No.:

10/364637

Inventors:

Robert McKenzie - Tampa FL, US

International Classification:

A61N005/00

US Classification:

600 8

Abstract:

A coupled seed train is formed by placing a plurality of seed train members into the lumen of a hollow tube. A plurality of accommodation slots are formed in the tube in spaced relation to one another along the length of the hollow tube. The members of the seed train are positioned within the lumen such that each accommodation slot is in registration with a space between contiguous members of the seed train. An adhesive is introduced into each accommodation slot to join the members of the train to one another in end-to-end relation with one another. The seed train and plunger are then placed into the lumen of a needle and the needle is introduced into the tissue of a patient. A plunger abuts the trailing end of the seed train and remains stationary as the needle is withdrawn over the seed train and plunger. The seed train is deployed at the proper position within the tissue. The needle and the plunger are then withdrawn from the tissue.

US Patent:

7150709, Dec 19, 2006

Filed:

Dec 24, 2004

Appl. No.:

11/021961

Inventors:

Bruno Schmidt - Tampa FL, US
Robert McKenzie - Tampa FL, US

International Classification:

A61M 36/00
A61N 5/00

US Classification:

600 7

Abstract:

A seeding needle lumen is adapted to receive a string of seeds and spacers. A dimple is formed in the seeding needle near its distal end and a protuberance formed by the dimple extends into the lumen. A hollow housing formed of a bio-absorbable, flexible and resilient material is positioned within the lumen in abutting relation to a trailing end of the protuberance. The hollow housing has an external diameter slightly less than a diameter of the lumen so that the hollow housing cannot slide past the protuberance and an internal diameter adapted to slidingly receive a seed or spacer positioned at a leading end of a string. The flexible and resilient material is momentarily deformable so that the hollow housing may squeeze past said protuberance when a stylet is maintained in a fixed position in abutting relation to a trailing end of the seeds and spacers when the seeding needle is withdrawn.

US Patent:

20050281737, Dec 22, 2005

Filed:

Oct 22, 2004

Appl. No.:

10/904099

Inventors:

John Kuperus - Tampa FL, US
Robert McKenzie - Tampa FL, US
Brooke Schumm - Ellicott City MD, US

Assignee:

ANAZAO HEALTH CORPORATION - Tampa FL

International Classification:

A61K051/00
F26B005/06

US Classification:

424001110, 034287000

Abstract:

A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration

US Patent:

20070104646, May 10, 2007

Filed:

Dec 21, 2006

Appl. No.:

11/614882

Inventors:

John Kuperus - Tampa FL, US
Robert McKenzie - Tampa FL, US
Brooke Schumm - Ellicott City MD, US

International Classification:

A61K 51/00

US Classification:

424001110, 424001490

Abstract:

A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.

US Patent:

20070128109, Jun 7, 2007

Filed:

Dec 21, 2006

Appl. No.:

11/614895

Inventors:

John Kuperus - Tampa FL, US
Robert McKenzie - Tampa FL, US
Brooke Schumm - Ellicott City MD, US

International Classification:

A61K 51/00

US Classification:

424001110, 424001490, 424001690

Abstract:

A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.

US Patent:

20070189965, Aug 16, 2007

Filed:

Jun 17, 2005

Appl. No.:

11/570774

Inventors:

John Kuperus - Tampa FL, US
Robert Mckenzie - Tampa FL, US
Brooke Schumm - Ellicott City MD, US

International Classification:

A61K 51/00

US Classification:

424001650

Abstract:

A novel method is set out of preparation of Copper isonitrile as a radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized from by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The Copper radiopharmaceutical is can be reconstituted and administered to a patient. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.

US Patent:

20080118433, May 22, 2008

Filed:

Jun 11, 2007

Appl. No.:

11/761364

Inventors:

Robert G. McKenzie - Tampa FL, US
Booke Schumm - Ellicott City MD, US

International Classification:

A61K 51/08
A61P 35/04

US Classification:

424 169

Abstract:

The inventors propose to label a chlorotoxin with I-123 or I-124 for a diagnostic agent, and with I-124 or I-131 for a therapeutic agent to reduce tumors and then to use a process they previously invented to stabilize the radiopharmaceutical. The inventors propose to reconstitute the preferred agents and administer them cyclically to diagnose and treat tumors. The inventors also propose a TETA or DOTA link to a metal radioisotope.