The present invention provides compostions and methods useful for treating and preventing neurodegenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.
Methods Of Treatment And Prevention Of Neurodegenerative Diseases And Disorders
Yi SHI - Boothwyn PA, US Robert NAGELE - Turnersville NJ, US
Assignee:
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - New Brunswick NJ THOMAS JEFFERSON UNIVERSITY - Philadelphia PA
International Classification:
A61K 31/517
US Classification:
5142581
Abstract:
The present invention provides compostions and methods useful for treating and preventing neurodenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.
Diagnostic Autoantibody Profiles For The Detection And Diagnosis Of Neurodegenerative Diseases
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ
International Classification:
G01N 33/68
US Classification:
506 9, 435 792, 506 18
Abstract:
The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.
Diagnostic Biomarkers For Detecting, Subtyping, And/Or Assessing Progression Of Multiple Sclerosis
- Glassboro NJ, US Robert G. Nagele - Turnersville NJ, US
International Classification:
G01N 33/564 G01N 33/552 G01N 33/53
Abstract:
Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.
Diagnostic Biomarkers For Detecting, Subtyping, And/Or Assessing Progression Of Multiple Sclerosis
- Glassboro NJ, US Robert G. Nagele - Turnersville NJ, US
International Classification:
G01N 33/564 G01N 33/552 G01N 33/53
Abstract:
Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.
Diagnostic Biomarkers For Detecting, Subtyping, And/Or Assessing Progression Of Multiple Sclerosis
- Glassboro NJ, US Robert G. Nagele - Turnersville NJ, US
International Classification:
G01N 33/564 G01N 33/552
Abstract:
Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.
- GLASSBORO NJ, US ROBERT G. NAGELE - TURNERSVILLE NJ, US
International Classification:
G01N 33/564 G01N 33/68
Abstract:
The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.
Diagnostic Biomarker Profiles For The Detection And Diagnosis Of Alzheimer's Disease
- Glassboro NJ, US Robert G. Nagele - Turnersville NJ, US
International Classification:
G01N 33/68 G01N 33/564
Abstract:
The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.
n a press release, about the discovery of the blood test, lead researcher Dr. Robert Nagele from Rowan University School of Osteopathic Medicine said that it is now believed that changes in a persons brain begin at least a decade prior to certain telltale symptoms of Alzheimers disease appear. Acc
Date: Jun 11, 2016
Category: Health
Source: Google
First blood test to use autoantibody biomarkers to detect early-stage Alzheimer's with 100% accuracy rate
Studys lead researcher Dr. Robert Nagele said that this is the first blood test that uses autoantibody biomarkers to detect Alzheimers at an early stage with great efficacy level. It would also be the time when treatments are more likely to be beneficial.
Date: Jun 11, 2016
Category: Health
Source: Google
New Blood Test Could Detect Early Stages of Alzheimer's
Dr. Robert Nagele, the research team leader, said the results now being reported were particularly important because pre-Alzheimer's changes in the brain begin "at least a decade before the emergence of telltale symptoms.
Robert Nagele, Ph.D., presenter of the latest findings at the Osteopathic Medical Conference and Exposition (OMED 15) in Orlando, has worked on autoanitibodies as primary biomarkers to indicate the presence of a disease and its stage. He foresees the benefit of early Alzheimer's disease detection as
Date: Oct 19, 2015
Category: Health
Source: Google
Blood Test May Spot Alzheimer's Before Symptoms Appear
''This is a simple test that has high accuracy and can be run from a single drop of blood," says Robert Nagele, PhD, a professor of medicine at the University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine. He is also founder of Durin Technologies Inc., the company that is de