Robert E Neal

US Patent:

20100030211, Feb 4, 2010

Filed:

Jun 24, 2009

Appl. No.:

12/491151

Inventors:

Rafael Davalos - Blacksburg VA, US
Paulo A. Garcia - Christianburg VA, US
John H. Rossmeisl - Blacksburg VA, US
John L. Robertson - Floyd VA, US
Robert E. Neal - Richmond VA, US

International Classification:

A61B 18/18
A61N 1/05

US Classification:

606 41, 607 72

Abstract:

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.

US Patent:

20130253415, Sep 26, 2013

Filed:

Nov 23, 2011

Appl. No.:

13/989175

Inventors:

Michael B. Sano - Blacksburg VA, US
Rafael V. Davalos - Blacksburg VA, US
John L. Robertson - Floyd VA, US
Paulo A. Garcia - Blacksburg VA, US
Robert E. Neal - Richmond VA, US

Assignee:

Virginia Tech Intellectual Properties, Inc. - Blacksburg VA

International Classification:

A61B 18/14
A61M 5/00

US Classification:

604 20, 606 41

Abstract:

The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

US Patent:

20200197073, Jun 25, 2020

Filed:

Jan 20, 2020

Appl. No.:

16/747219

Inventors:

- Blacksburg VA, US
Rafael V. Davalos - Blacksburg VA, US
John L. Robertson - Floyd VA, US
Paulo A. Garcia - Cambridge MA, US
Robert E. Neal - Richmond VA, US

International Classification:

A61B 18/14
A61M 5/00
A61K 48/00

Abstract:

The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

US Patent:

20180125565, May 10, 2018

Filed:

Dec 15, 2017

Appl. No.:

15/843888

Inventors:

- Blacksburg VA, US
Rafael V. Davalos - Blacksburg VA, US
John L. Robertson - Floyd VA, US
Paulo A. Garcia - Blacksburg VA, US
Robert E. Neal - Richmond VA, US

International Classification:

A61B 18/14
A61M 5/00
A61K 48/00
A61B 18/00
A61N 1/32

Abstract:

The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.