Robert S Neuwirth

US Patent:

7419687, Sep 2, 2008

Filed:

Apr 16, 2004

Appl. No.:

10/825930

Inventors:

Robert S. Neuwirth - Englewood NJ, US

Assignee:

Ablation Products LLC - Englewood NJ

International Classification:

A61K 33/38
A61K 9/64
A61K 9/14
A61K 31/28
A61K 47/30
A01N 55/02
A01N 25/26
A01N 59/16

US Classification:

424618, 424417, 424456, 424489, 514495, 5147723

Abstract:

A delivery vehicle for a silver ion source such as silver nitrate and the like, suitable for use in the treatment of menorrhagia, comprises a plurality of physiologically inert beads bearing a tissue cauterizing amount of a silver ion source. Preferably the beads are made of a physiologically inert polymer, ceramic or stainless steel. The silver ion source preferably is silver nitrate and can be substantially pure silver nitrate, or can comprise silver nitrate in combination with a physiologically tolerable binder or a diluent. Suitable binders include physiologically tolerable synthetic polymeric binders, polysaccharide binders, and the like. Diluents can include other salt materials such as potassium nitrate. The beads are useful in treating menorrhagia of a mammalian uterus. The beads can be delivered to the uterus via a catheter, and are distributed throughout the uterine cavity by uterine massage or like expedient.

US Patent:

7875297, Jan 25, 2011

Filed:

Sep 2, 2008

Appl. No.:

12/231340

Inventors:

Robert S. Neuwirth - Englewood NJ, US

Assignee:

Ablation Products LLC - Englewood NJ

International Classification:

A61K 33/38
A61K 33/00
A01N 59/16
A01N 59/00

US Classification:

424618, 424718

Abstract:

A delivery vehicle for a silver ion source such as silver nitrate and the like, suitable for use in the treatment of menorrhagia, comprises a plurality of physiologically inert beads bearing a tissue cauterizing amount of a silver ion source. Preferably the beads are made of a physiologically inert polymer, ceramic or stainless steel. The silver ion source preferably is silver nitrate and can be substantially pure silver nitrate, or can comprise silver nitrate in combination with a physiologically tolerable binder or a diluent. Suitable binders include physiologically tolerable synthetic polymeric binders, polysaccharide binders, and the like. Diluents can include other salt materials such as potassium nitrate. The beads are useful in treating menorrhagia of a mammalian uterus. The beads can be delivered to the uterus via a catheter, and are distributed throughout the uterine cavity by uterine massage or like expedient.

US Patent:

8609141, Dec 17, 2013

Filed:

Sep 1, 2009

Appl. No.:

12/737859

Inventors:

Robert S. Neuwirth - Englewood NJ, US

Assignee:

Ablation Products LLC - Englewood NJ

International Classification:

A61K 33/38
A61K 9/64
A61K 9/14
A61K 31/28
A61K 47/30
A01N 55/02
A01N 25/26
A01N 59/16

US Classification:

424468, 424417, 424456, 424489, 514495, 5147723

Abstract:

The present invention pertains to silver ion bearing carriers useful in treating monorrhagia of a mammalian uterus, comprising a physiologically inert, flexible earner, e. g. , a coil, bearing a tissue cauterizing amount of a silver ion. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e. g. , by catheter, and the carrier recovered from the uterus.

US Patent:

8042548, Oct 25, 2011

Filed:

Oct 27, 2006

Appl. No.:

12/084185

Inventors:

Robert S. Neuwirth - Englewood NJ, US
Michel Gensini - Flemington NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

A61F 6/06
A61F 13/20
A61B 17/42

US Classification:

128831, 606119, 604 11, 424430

Abstract:

A method for inducing Fallopian tube blockage as a means for female contraception comprises contacting the inner surface tissue of a Fallopian tube with a silver nitrate bearing substrate and delivering an amount of silver nitrate to the tissue sufficient to induce blockage of the Fallopian tube. At least one silver nitrate bearing bead is introduced through the uterine opening of the Fallopian tube by use of a catheter or other device suitable for manipulating the bead. Alternatively, a plurality of beads can be introduced into the Fallopian tube. In a preferred embodiment, one or more silver nitrate bearing beads are arranged on a string to facilitate later removal of the beads. The method of the present invention delivers an amount of silver nitrate to the tissue sufficient to cause tissue necrosis and blockage of the Fallopian tube.

US Patent:

54606284, Oct 24, 1995

Filed:

Sep 30, 1992

Appl. No.:

7/954226

Inventors:

Robert S. Neuwirth - Englewood NJ
Lee R. Bolduc - Raleigh NC

International Classification:

A61F 712

US Classification:

606 28

Abstract:

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, heating the fluid by means located internal to the bladder to a temperature of 190. degree. to 215. degree. F. and preferably 210. degree. F. for a period of 4 to 12 minutes and preferably 6 minutes and regulating said apparatus by means located external to the uterus, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium. An agitator circulates the fluid within the distendable bladder to help keep the fluid at a uniform temperature.

US Patent:

58914579, Apr 6, 1999

Filed:

May 12, 1997

Appl. No.:

8/854604

Inventors:

Robert S. Neuwirth - Englewood NJ

International Classification:

A61F 606
A61M 3100

US Classification:

424430

Abstract:

A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e. g. , a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e. g. , an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.

US Patent:

61973513, Mar 6, 2001

Filed:

Sep 17, 1997

Appl. No.:

8/932727

Inventors:

Robert S. Neuwirth - Englewood NJ

International Classification:

A61K 3338
A61K 3128

US Classification:

424618

Abstract:

A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e. g. , a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e. g. , an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.

US Patent:

55016812, Mar 26, 1996

Filed:

Nov 12, 1993

Appl. No.:

8/151709

Inventors:

Robert S. Neuwirth - Englewood NJ
Lee R. Bolduc - Raleigh NC

International Classification:

A61B 1700

US Classification:

606 21

Abstract:

A method and apparatus for effecting necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by introducing an applicator comprising a distendable bladder connected to a catheter into the uterus, distending the bladder by introducing a non-toxic fluid under pressure, cooling the fluid by means located internal to the bladder to a temperature below 32. degree. F. for a period of about 4 to about 12 minutes and preferably about 6 minutes, thereby cauterizing substantially the entirety of the tissue lining, particularly the endometrium.