Robert W Nichols

US Patent:

7919279, Apr 5, 2011

Filed:

Sep 21, 2006

Appl. No.:

12/088229

Inventors:

Elizabeth A. Trachtenberg - Oakland CA, US
Kathleen Houtchens - Oakland CA, US
Robert J. Nichols - Oakland CA, US

Assignee:

Children's Hospital & Research Center at Oakland - Oakland CA

International Classification:

C12P 19/34
C07H 21/04

US Classification:

435 912, 536 2433

Abstract:

The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In general, the methods involve amplifying a plurality of target sequences of a plurality of KIR genes, and detecting the presence or absence of a plurality of single SNPs of the plurality of KIR genes by MALDI-TOF mass spectrometry. The invention also features compositions, including arrays of capture primers and optionally extension primers on a substrate surface, and kits, for use in the methods of the invention.

US Patent:

20210154190, May 27, 2021

Filed:

Oct 6, 2020

Appl. No.:

17/064317

Inventors:

- Redwood City CA, US
Robert J. NICHOLS - Redwood City CA, US

International Classification:

A61K 31/497
A61K 31/551
A61K 31/4965
A61K 31/55
A61K 31/517
A61P 35/00

Abstract:

The present disclosure provides methods of treating diseases or disorders related to mutations in the SHP2 gene using allosteric inhibitors of SHP2 and methods and diagnostic tests for identifying subjects susceptible or resistant to allosteric inhibitors of SHP2. In particular, the present disclosure provides allosteric inhibitor-sensitive mutations and allosteric inhibitor-resistant mutations of SHP2 for diagnostic and therapeutic use.