Robert S O'Neill

US Patent:

6890710, May 10, 2005

Filed:

May 19, 1995

Appl. No.:

08/444994

Inventors:

Peter Palese - Leoma NJ, US
Robert O'Neill - New York NY, US

Assignee:

Mount Sinai School of Medicine of New York University - New York NY

International Classification:

C12Q001/70

US Classification:

435 5, 435 71, 4242061

Abstract:

The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

US Patent:

7498424, Mar 3, 2009

Filed:

Nov 24, 2003

Appl. No.:

10/724273

Inventors:

Peter Palese - Leonia NJ, US
Robert O'Neill - New York NY, US

Assignee:

Mount Sinai School of Medicine of New York University - New York NY

International Classification:

C07H 21/02

US Classification:

536 231, 4242091

Abstract:

The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

US Patent:

7632801, Dec 15, 2009

Filed:

Jan 6, 2003

Appl. No.:

10/337213

Inventors:

Peter M. Palese - Leonia NJ, US
Robert O'Neill - Yonkers NY, US
Ronald Harty - Bensalem PA, US

Assignee:

Mount Sinai School of Medicine of New York University - New York NY

International Classification:

A61K 38/00
A61K 38/08
A61K 38/10
C07K 4/00
C07K 4/02
C07K 7/00

US Classification:

514 2, 530300, 530326, 530327

Abstract:

The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between viral proteins and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP. Also, host cell proteins, referred to herein as NS1I-1 and NS1-BP interact with influenza virus protein NS. In addition, host cell proteins containing WW domains that interact with viral proteins such as Rhabdoviral M protein are described. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

US Patent:

40501027, Sep 27, 1977

Filed:

Mar 5, 1976

Appl. No.:

5/664299

Inventors:

James M. Kemper - Santa Monica CA
Robert J. O'Neill - Santa Monica CA
Bruce E. Wagenhals - Santa Monica CA
Jack W. Adams - Santa Monica CA

Assignee:

Monogram Industries, Inc. - Los Angeles CA

International Classification:

E03D 516

US Classification:

4 10

Abstract:

Improvements in a recirculating toilet system wherein at least one human waste receiving receptacle, such as a urinal or toilet bowl, is provided coupled to a separating tank having a predetermined amount of a non-aqueous flushing fluid of a lower density and specific gravity than water therein. A flushing fluid intake floats on top of a layer of the flushing fluid in the tank with water and human waste below the layer. A motor-activated pump flushing fluid recirculating means is coupled to both the intake and the receptacle for withdrawing flushing fluid from the layer in the tank and flushing the receptacle. The float has a detector for detecting the presence of a predetermined amount of wastewater in the flushing fluid being withdrawn from the tank for flushing the receptacle and for detecting the level of the flushing fluid in the tank and deactivates the pump of the recirculating means when this predetermined amount of wastewater is detected.

US Patent:

57503940, May 12, 1998

Filed:

May 20, 1994

Appl. No.:

8/246583

Inventors:

Peter Palese - Leonia NJ
Robert O'Neill - New York NY

Assignee:

The Mount Sinai Medical Center - New York NY

International Classification:

C12N 121
C12N 1563
C12N 510
C07H 2104

US Classification:

4352523

Abstract:

The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the discovery described herein of a novel interaction between the NP of influenza virus and a human host cell protein. The host cell protein, referred to herein as NPI-1, may be an accessory protein required for replication of influenza virus. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.

US Patent:

20180127868, May 10, 2018

Filed:

Dec 15, 2017

Appl. No.:

15/843683

Inventors:

- Fremont CA, US
Hong SHIH - Walnut CA, US
Nash ANDERSON - Cupertino CA, US
Tom STEVENSON - Morgan Hill CA, US
John DAUGHERTY - Fremont CA, US
John Michael KERNS - Livermore CA, US
Robert Griffith O'NEILL - Hayward CA, US

International Classification:

C23C 14/56
C23C 16/455
C23C 16/44
C23C 16/04

Abstract:

A fluid handling component for a vacuum chamber of a semiconductor substrate processing apparatus is provided. The fluid handling component comprises interior fluid wetted surfaces and an atomic layer deposition (ALD) or molecular layer deposition (MLD) barrier coating on the interior fluid wetted surfaces wherein the fluid wetted surfaces which include the ALD or MLD barrier coating are configured to be contacted by a process gas and/or fluid during a semiconductor substrate processing process wherein the ALD or MLD barrier coating protects the underlying fluid wetted surfaces from erosion and/or corrosion.

US Patent:

20160370690, Dec 22, 2016

Filed:

Sep 2, 2016

Appl. No.:

15/256439

Inventors:

- Huntington Beach CA, US
Chong Pak - Lakewood CA, US
Joshua Cantor - Huntington Beach CA, US
Jason Patrick - Long Beach CA, US
Daniel Arato - Los Angeles CA, US
Ryan Nguyen - Fountain Valley CA, US
Robert O'Neill - Huntington Beach CA, US

International Classification:

G03B 17/56
H04N 5/225
G02B 15/10
G02B 13/00
G02B 7/02
G02B 7/14

Abstract:

A multi-lens system can be configured to be selectively attachable to a mobile electronic device having a user-facing onboard camera lens and an outward-facing onboard camera lens. The multi-lens system can attach to the mobile electronic device in at least a first position and a second position. The first lens component in the first position is configured to be in optical alignment with the user-facing onboard camera lens and simultaneously the second lens component is configured to be in optical alignment with the outward-facing onboard camera lens. The first lens component in the second position is configured to be in optical alignment with the outward-facing onboard camera lens and simultaneously the second lens component is configured to be in optical alignment with the user-facing onboard camera lens. A portable attachment accessory can be configured to be selectively attachable to a lens system that is configured to receive a portion of a mobile electronic device.

US Patent:

20160373155, Dec 22, 2016

Filed:

Jun 21, 2016

Appl. No.:

15/188764

Inventors:

- Huntington Beach CA, US
Chong Pak - Lakewood CA, US
Jason Patrick - Long Beach CA, US
Daniel Arato - Los Angeles CA, US
Joshua Cantor - Huntington Beach CA, US
Ryan Nguyen - Fountain Valley CA, US
Robert O'Neill - Huntington Beach CA, US

International Classification:

H04B 1/3888
A45C 11/00

Abstract:

Removably-attachable cases for mobile electronic devices are provided. A removably-attachable case may include an attachment region to which accessories can be attached for use with the mobile electronic device onto which the case has been installed. The accessories may include illumination components (e.g., flashes for flash photography), recording components (e.g., microphones), support components (e.g., tripods, handles), other accessories, accessory mounting components, some combination thereof, etc. A removably attachable case may also or alternatively include an access region configured to provide access to a component of a mobile electronic device onto which the case is removably attached.