A paint booth airflow control system is described for preventing paint particles and other contaminates from entering adjacent paint booth sections by equalizing air pressure differences between adjacent sections. Pressure sensors in communication with adjacent paint booth sections report pressure differences between the adjacent sections to an airflow controller. Responsive to the reported pressure differences the airflow controller adjusts paint booth airflow to equalize the pressure between adjacent sections. In order to maintain pressure measurement accuracy, automatic calibration modules periodically calibrate all pressure sensors to pneumatic references.