Robert A Pierce

US Patent:

8252846, Aug 28, 2012

Filed:

Mar 12, 2008

Appl. No.:

12/075667

Inventors:

Niren Murthy - Atlanta GA, US
Bali Pulendran - Alpharetta GA, US
Robert H. Pierce - Palo Alto CA, US
Michael John Heffernan - Atlanta GA, US
Jihua Hao - Cleveland OH, US
Michael Davis - Atlanta GA, US
Stephen C. Yang - Mableton GA, US

Assignee:

Emory University - Atlanta GA
Georgia Tech Research Corporation - Atlanta GA
University of Rochester - Rochester NY

International Classification:

A61K 47/30
A61K 38/18
A61K 31/70
A61K 47/48
A01N 43/04
C08G 2/00

US Classification:

5147723, 514 76, 514 23, 525 541, 525 542, 528220

Abstract:

The present invention provides biodegradable particles (e. g. , three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.

US Patent:

20100062968, Mar 11, 2010

Filed:

May 10, 2006

Appl. No.:

11/920330

Inventors:

Bali Pulendran - Alpharetta GA, US
Niren Murthy - Atlanta GA, US
Robert H. Pierce - Rochester NY, US
Michael John Heffernan - Atlanta GA, US
Jihua Hao - Cleveland OH, US

International Classification:

A61K 47/00
C08G 65/34
A61K 31/7088
A61P 37/00
A61P 35/00
A61P 31/12
A61P 3/10
C07K 1/00
A61K 38/00

US Classification:

514 2, 528425, 5147723, 530345, 514 44 A, 424 7827, 525 542

Abstract:

The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.

US Patent:

50733443, Dec 17, 1991

Filed:

Jul 21, 1988

Appl. No.:

7/222812

Inventors:

Michael W. Smith - Peachtree City GA
Robert S. Pierce - Smyrna GA

Assignee:

Porex Technologies Corp. - Fairburn GA

International Classification:

G01N 3122

US Classification:

422 69

Abstract:

In a diagnostic apparatus system, a one piece porous substrate is located in a container. The substrate serves both to extract an antigen in or on a top layer with the remainder of the substrate serving as a reservoir. The pores in the top surface of the substrate are microscopic for entrapment of microspheres carrying antibodies. A target antigen in a test sample attaches to the antibodies when the test sample is poured through the top layer. The pores in all but the top layer of the substrate have a much greater pore size to define the reservoir portion of the substrate. The invention also includes a method of casting a microporous matrix in surfaces of a plurality of macroporous slugs. The method includes the steps of selecting a casting apparatus that defines openings for receiving the slugs and wells that are adjacent to the openings, positioning the slugs in the openings with the surfaces facing upward, the surfaces being positioned adjacent to the wells, dispensing a casting solution into the wells so that the solution contacts the surfaces, and allowing at least a portion of the solution to wick into the slugs and harden so that the microporous matrix is cast in the surfaces. The invention also includes an apparatus for practicing the method.

US Patent:

54321000, Jul 11, 1995

Filed:

Dec 13, 1991

Appl. No.:

7/806290

Inventors:

Michael W. Smith - Fairburn GA
Robert S. Pierce - Smyrna GA

Assignee:

Porex Technologies Corp. - Fairburn GA

International Classification:

G01N 33543
G01N 33545
G01N 33546

US Classification:

436533

Abstract:

In a diagnostic apparatus system, a one piece porous substrate is provided in a container. The substrate serves both to extract an antigen in or on a top layer thereof with the remainder of the substrate serving as a reservoir. The pores in the top surface of the substrate are microscopic for entrapment of microspheres carrying antibodies. A target antigen in a test sample attaches to the antibodies when the test sample is poured through the top layer. The pores in all but the top layer of the substrate have a much greater pore size to comprise tile reservoir portion of the substrate.