Robert R Richard

US Patent:

7241455, Jul 10, 2007

Filed:

Apr 8, 2003

Appl. No.:

10/409358

Inventors:

Robert E. Richard - Wrentham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 2/00
A61K 47/30

US Classification:

424423, 5147723

Abstract:

An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric release region is crosslinked with a radiation dose of at least 10,000 rads. The radiation-crosslinked polymer can be, for example, a radiation-crosslinked methylene-containing polymer. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.

US Patent:

7285018, Oct 23, 2007

Filed:

Jun 23, 2004

Appl. No.:

10/874837

Inventors:

William A. Kenny - Amherst NH, US
Thomas S. Cohen - New Boston NH, US
Robert A. Richard - New Boston NH, US

Assignee:

Amphenol Corporation - Wallingford CT

International Classification:

H01R 13/66

US Classification:

43962001

Abstract:

An electrical connector that electrically connects a first printed circuit board and a second printed circuit board is disclosed, where the electrical connector in the preferred embodiment includes: (a) an insulative housing; (b) a plurality of signal conductors, with at least a portion of each of the plurality of signal conductors disposed within the insulative housing; (c) each of the plurality of signal conductors having a first contact end, a second contact end and an intermediate portion therebetween; and (d) a passive circuit element electrically connected to the intermediate portion of each of the plurality of signal conductors, where the passive circuit element is housed in an insulative package and includes at least a capacitor or an inductor.

US Patent:

7357940, Apr 15, 2008

Filed:

Jul 31, 2003

Appl. No.:

10/632413

Inventors:

Robert E. Richard - Wrentham MA, US
Frederick H. Strickler - Natick MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 13/00

US Classification:

424422, 6048901, 6048911

Abstract:

Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymer release region comprises a graft copolymer, which further comprises a main chain and a plurality of side chains. One of (a) the main chain and (b) the side chains corresponds to a rubbery phase within the release region at ambient temperatures, while the other corresponds to a hard phase within the release layer at ambient temperatures. Typically, the graft copolymer will comprise one glass transition temperature below ambient temperature and another second glass transition temperature above ambient temperature. Also described are methods for forming the above graft copolymers, methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices, as well as methods for making the above devices.

US Patent:

7381418, Jun 3, 2008

Filed:

Jul 5, 2007

Appl. No.:

11/825383

Inventors:

Robert E. Richard - Wrentham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 2/00
A61K 47/30

US Classification:

424423, 5147723

Abstract:

An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric release region is crosslinked with a radiation dose of at least 10,000 rads. The radiation-crosslinked polymer can be, for example, a radiation-crosslinked methylene-containing polymer. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.

US Patent:

7491234, Feb 17, 2009

Filed:

Dec 3, 2002

Appl. No.:

10/308587

Inventors:

Maria Palasis - Wellesley MA, US
Wendy Naimark - Cambridge MA, US
Robert E. Richard - Wrentham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 2/06

US Classification:

623 142, 424423

Abstract:

The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.

US Patent:

7517914, Apr 14, 2009

Filed:

Apr 4, 2005

Appl. No.:

11/098729

Inventors:

Robert E. Richard - Wrentham MA, US

Assignee:

Boston ScientificScimed, Inc. - Maple Grove MN

International Classification:

A61K 47/00
A61K 47/30
A61K 47/32

US Classification:

5147721, 5147723, 5147724, 5147726

Abstract:

According to an aspect of the present invention, polymeric release regions are provided, which contain one or more partially biodegradable progenitor polymers and which control the release of one or more therapeutic agents disposed beneath or within the same. The progenitor polymers within the release regions are composed of a plurality of biostable polymer portions (which may be the same or different from one another) linked via one or more biodegradable linkages. Upon implantation or insertion into the body, the linkages degrade, cleaving the progenitor polymers into two or more biostable polymers of reduced molecular weight (relative to the molecular weight of the progenitor polymers). As a consequence of this reduction in molecular weight, the release characteristics of the release regions change over time.

US Patent:

7537781, May 26, 2009

Filed:

Feb 12, 2004

Appl. No.:

10/777801

Inventors:

Robert E. Richard - Wrentham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 2/82

US Classification:

424425, 425423, 425424

Abstract:

A medical article comprising: (a) a therapeutic agent; and (b) a release region comprising (i) a polymer and (ii) a filler comprising inorganic platelet particles. Upon placement of such a medical article at a position on or within a patient, the release region regulates the rate of release of the therapeutic agent from the medical article to the patient. An example of a filler is one comprising inorganic platelet particles. Examples of medical articles include, for instance, drug delivery patches, and implantable or insertable medical devices. Also described are methods of releasing a therapeutic agent to a patient using such medical articles, and methods of making such medical articles.

US Patent:

7540781, Jun 2, 2009

Filed:

Sep 24, 2007

Appl. No.:

11/902551

Inventors:

William A. Kenny - Amherst NH, US
Thomas S. Cohen - New Boston NH, US
Robert A. Richard - New Boston NH, US

Assignee:

Amphenol Corporation - Wallingford CT

International Classification:

H01R 13/66

US Classification:

43962016

Abstract:

An electrical connector that electrically connects a first printed circuit board and a second printed circuit board is disclosed, where the electrical connector in the preferred embodiment includes: (a) an insulative housing; (b) a plurality of signal conductors, with at least a portion of each of the plurality of signal conductors disposed within the insulative housing; (c) each of the plurality of signal conductors having a first contact end, a second contact end and an intermediate portion therebetween; and (d) a passive circuit element electrically connected to the intermediate portion of each of the plurality of signal conductors, where the passive circuit element is housed in an insulative package and includes at least a capacitor or an inductor.