Robert B Roby

US Patent:

48014508, Jan 31, 1989

Filed:

May 5, 1986

Appl. No.:

6/859944

Inventors:

Michael S. Collins - Pinole CA
Robert E. Roby - Pinole CA

Assignee:

Miles Laboratories, Inc. - Elkhart IN

International Classification:

A61K 3940

US Classification:

424 87

Abstract:

Normal plasma from donors who have not been vaccinated with a P seudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four or, preferably, two of seven Fisher Immunotypes of Pseudomonas. Those plasmas with higher titers of such antibody can be pooled and fractionated to give hyperimmune serum globulin having high titers of antibody against all seven Fisher Immunotypes. The product may be treated to render it intravenously injectable and the so-prepared material is effective in treating patients with Pseudomonas infection. Also disclosed is a novel antibody preparation including minimum titers of the seven Fisher Immunotypes.

US Patent:

45871213, May 6, 1986

Filed:

Jun 17, 1983

Appl. No.:

6/504106

Inventors:

Michael S. Collins - Richmond CA
Robert E. Roby - Pinole CA

Assignee:

Miles Laboratories, Inc. - Elkhart IN

International Classification:

A61K 39395
A61K 3940
C07K 1500
C07K 300

US Classification:

424 87

Abstract:

Normal plasma from donors who have not been vaccinated with a Pseudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four of seven Fisher Immunotypes for Pseudomonas. Those plasmas with higher titers of such antibody can be pooled and fractionated to give hyperimmune serum globulin having high titers of antibody against all seven Fisher Immunotypes. The product may be treated to render it intravenously injectable and the so-prepared material is effective in treating patients with Pseudomonas infection.