Robert A Schultz

US Patent:

42671264, May 12, 1981

Filed:

Jan 23, 1980

Appl. No.:

6/114624

Inventors:

Robert J. Schultz - Amherst NY
Fred W. Starks - Kenmore NY

Assignee:

Starks Associates, Inc. - Buffalo NY

International Classification:

C07F 940
A61K 3166

US Classification:

260942

Abstract:

N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.

US Patent:

41794648, Dec 18, 1979

Filed:

Aug 10, 1978

Appl. No.:

5/932501

Inventors:

Robert J. Schultz - Amherst NY
Fred W. Starks - Kenmore NY

International Classification:

C07F 938

US Classification:

2605025

Abstract:

Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. Particular aspects of these methods include: (1) initial preparation of the PALA moiety as the dibenzyl ester; (2) the complete removal of impurities in the form of acetic acid and sodium acetate from disodium PALA by turbulent flow precipitation; and (3) preparation and purification of the cyclohexylammonium salt of dibenzyl PALA which ultimately results in a purer final product.

US Patent:

42150701, Jul 29, 1980

Filed:

Oct 25, 1978

Appl. No.:

5/954579

Inventors:

Robert J. Schultz - Amherst NY
Fred W. Starks - Kenmore NY

Assignee:

Starks Associates, Inc. - Buffalo NY

International Classification:

C07F 938

US Classification:

2605025

Abstract:

N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.

US Patent:

43485227, Sep 7, 1982

Filed:

May 8, 1981

Appl. No.:

6/261915

Inventors:

Robert J. Schultz - Amherst NY
Fred W. Starks - Kenmore NY

Assignee:

Starks Associates, Inc. - Buffalo NY

International Classification:

C07D29500

US Classification:

544358

Abstract:

N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.