Michael R. Boyd - Ijamsville MD, US Kirk R. Gustafson - Frederick MD, US Robert H. Shoemaker - Frederick MD, US James B. McMahon - Frederick MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 31/70
US Classification:
514 44, 424 931, 424 932, 424 9321
Abstract:
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
Identification Of Anti-Hiv Compounds Inhibiting Virus Assembly And Binding Of Nucleocapsid Protein To Nucleic Acid
Robert H. Shoemaker - Boyds MD, US Michael Currens - Frederick MD, US Alan Rein - Columbia MD, US Hang Yuan, legal representative - Bethesda MD, US Robert Fisher - Sharpsburg MD, US Andrew Stephen - Catonsville MD, US Karen Worthy - Germantown MD, US Shizuko Sei - Bethesda MD, US Bruce Crise - Washington Grove MD, US Louis E. Henderson - Mt. Airy MD, US
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
Kinase Inhibitors, Compositions Thereof, And Methods Of Use Therewith
Robert Shoemaker - Boyds MD, US John Cardellina - Walkersville MD, US Michael Currens - Frederick MD, US Sudhir Kondapaka - North Potomac MD, US Yves Pommier - Bethesda MD, US Andy Jobson - Rockville MD, US Dominic Scudiero - Frederick MD, US David Waugh - Walkersville MD, US George Lountos - Frederick MD, US Charles M. Cook - Mendham NJ, US Guangtao Zhang - Princeton NJ, US Andrew Colasanti - Scotch Plains NJ, US Christopher R. Self - West Caldwell NJ, US Janet Cicariello Cook - Mendham NJ, US
A method for the prevention or treatment of Kaposi's sarcoma or Kaposi's sarcoma-associated herpes virus infection by administering an effective amount of a cyclopropanated carbocyclic 2′-deoxynucleoside to an individual in need thereof is provided.
Use Of Chk2 Kinase Inhibitors For Cancer Treatment
Yves Pommier - Bethesda MD, US Robert H. Shoemaker - Boyds MD, US Dominic Scudiero - Frederick MD, US Michael Currens - Frederick MD, US John Cardellina - Walkersville MD, US Andrew Jobson - Rockville MD, US
Assignee:
Government of the US, as represented by the Secretary, Department of Health and Human Services - Rockville MD
Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Michael R. Boyd - Ijamsville MD Kirk R. Gustafson - Frederick MD Robert H. Shoemaker - Frederick MD James B. McMahon - Frederick MD
Assignee:
The United States of America, represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
C07K 1608
US Classification:
5303879
Abstract:
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
Conjugates Of Antiviral Proteins Or Peptides And Virus Or Viral Envelope Glycoproteins
Michael R. Boyd - Ijamsville MD Kirk R. Gustafson - Frederick MD Robert H. Shoemaker - Potomac MD James B. McMahon - Frederick MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 3808 A61K 3810 A61K 3816
US Classification:
514 2
Abstract:
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
Nucleic Acids Encoding Antiviral Proteins And Peptides Fused To Effector Proteins
Michael R. Boyd - Ijamsville MD Robert H. Shoemaker - Frederick MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12N 1511
US Classification:
536 234
Abstract:
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.