Robert L Snow

US Patent:

6350431, Feb 26, 2002

Filed:

Oct 28, 1999

Appl. No.:

09/429347

Inventors:

Robert Allen Snow - West Chester PA
Paul Mark Henrichs - Houston TX
Daniel Joseph Delecki - Radnor PA
William Anthony Sanderson - late of Wayne PA
Vinay Chandrakant Desai - Phoenixville PA
Edward Bacon - Audubon PA
Kenneth Robert Hollister - Chester Springs PA
Eric Paul Hohenschuh - Berwyn PA

Assignee:

Nycomed Imaging AS - Oslo

International Classification:

A61K 4900

US Classification:

424 96, 548 3, 548223, 549402, 549427, 549455

Abstract:

This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkylene oxide (PAO) moiety having a molecular weight in the range 60 to 100000.

US Patent:

6423296, Jul 23, 2002

Filed:

Feb 22, 1999

Appl. No.:

09/101528

Inventors:

Wolfgang Gunther - West Chester PA
Kenneth Kellar - Wayne PA
Dennis Kiyoshi Fujii - Downingtown PA
Vinay Desai - Wayne PA
Christopher Black - Wayne PA
Marshall Beeber - Royersford PA
Jennifer Wellons - Wayne PA
Anne Kjersti Fahlvik - Oslo, NO
Jasbir Singh - Gilbertsville PA
Edward Richard Bacon - Wayne PA
Gregory Lynn McIntire - Wayne PA
Robert Alan Snow - Wayne PA
Brian Weekley - Wayne PA
Torgrim Engell - Oslo, NO
Michel Gacek - Hovik, NO
David Lee Ladd - Wayne PA
Anne Naevestad - Oslo, NO
George Na - Wayne PA
Barbara Yuan - Wayne PA
Jack Stevens - Wayne PA

Assignee:

Amersham Health AS - Oslo

International Classification:

A61B 5055

US Classification:

424 9322, 424 93, 424 932, 424 91

Abstract:

The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

US Patent:

6596097, Jul 22, 2003

Filed:

May 24, 2000

Appl. No.:

09/577441

Inventors:

Robert Snow - West Chester PA
Gregory McIntire - West Chester PA
Edward Bacon - Audubon PA
Evan Gustow - Villanova PA

Assignee:

Amersham, PLC - Little Chalfont

International Classification:

C23C 1816

US Classification:

148283, 148253, 148243, 148264

Abstract:

A method for the immobilization of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidizing agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is I and the binding agent comprises bromide ions.

US Patent:

6632176, Oct 14, 2003

Filed:

May 17, 2001

Appl. No.:

09/860011

Inventors:

Gregory McIntire - West Chester PA
Robert Snow - West Chester PA
Edward Bacon - Audubon PA
Morten Eriksen - Oslo, NO
Auden Tornes - Oslo, NO
Geraldine Cooney - Gilbertsville PA
Virginia Ann Gates - Collegeville PA
Joel Cornacoff - Audubon PA
Christopher Black - Norristown PA

Assignee:

Amersham PLC - Buckinghamshire

International Classification:

A61B 800

US Classification:

600439, 600 3, 600 8

Abstract:

Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patients body. Preferred radioisotopes are palladium-103 and iodine-125.

US Patent:

6689043, Feb 10, 2004

Filed:

Jul 23, 2001

Appl. No.:

09/831229

Inventors:

Gregory McIntire - West Chester PA
Robert Snow - West Chester PA
Edward Bacon - Audubon PA
Morten Eriksen - Oslo, NO
Auden Tornes - Oslo, NO
Geraldine Cooney - Gilbertsville PA
Christopher Black - Norristown PA
Joel Cornacoff - Audubon PA
Virginia Ann Gates - Collegeville PA

Assignee:

Amersham PLC - Little Chalfont

International Classification:

A61N 500

US Classification:

600 1, 424 129

Abstract:

Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patients body. Preferred radioisotopes are palladium-103 and iodine-125.

US Patent:

6749554, Jun 15, 2004

Filed:

Jan 11, 2002

Appl. No.:

09/914161

Inventors:

Robert Allen Snow - West Chester PA
Henry Wolfe - Glenmore PA
Anna Rydbeck - Malmo, SE
Tore Gjorsvik - Oslo, NO
Steven Coffey - Pawcatuck CT
Hakan Malmgren - Malmo, SE
Oskar Axellson - Malmo, SE

Assignee:

Amersham PLC - Buckinghamshire

International Classification:

A61N 500

US Classification:

600 3, 600458

Abstract:

A medical or surgical device or tool that is designed to be implanted or inserted inside the human or mammalian body, having at least part of its surface coated whereby the ultrasound visibility of said device or tool in vivo is enhanced, wherein the coating comprises one or more of the following: (i) a matrix material containing a plurality of contrast enhancing elements; (ii) magnesium; (iii) a liquid or polymer which alters its ultrasound imaging properties upon elevating the temperature from ambient to physiological temperature; (iv) a liquid or polymer which alters its ultrasound imaging properties as a result of a change in pH; (v) an essentially non-polymeric bio-compatible compound which forms a discontinuous coating. Preferably the device or tool is a radioactive source for use in brachytherapy, and in particular a radioactive seed.

US Patent:

7011619, Mar 14, 2006

Filed:

Aug 13, 1999

Appl. No.:

09/763006

Inventors:

Dewi M. Lewis - Prestwood, GB
Lucinda A. Dollimore - Gerrards Cross, GB
Nigel Powell - Reading, GB
Gregory L. McIntire - West Chester PA, US
Evan Gustow - Villanova PA, US
Robert A. Snow - West Chester PA, US

Assignee:

GE Healthcare Limited - Buckinghamshire

International Classification:

A61N 5/00

US Classification:

600 3, 600 1, 600 7, 600 8

Abstract:

The invention provides the use of a radiation source which is a low energy X-ray emitter, e. g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.

US Patent:

7572913, Aug 11, 2009

Filed:

Feb 24, 2005

Appl. No.:

11/065696

Inventors:

Lisa McKerracher - Iles-des-Soeurs, CA
Eryk Thouin - Montréal, CA
William Lubell - Montréal, CA
Robert Snow - West Chester PA, US
Karine Gingras - Montréal, CA

Assignee:

Bioaxone Therapeutique Inc.

International Classification:

C07D 217/22
C07D 215/38
A61K 31/47

US Classification:

546141, 546169, 514309, 514312

Abstract:

Substituted piperidine compounds represented by the structure I are provided,.