Robert Lee Townsend

US Patent:

6346602, Feb 12, 2002

Filed:

Feb 6, 1998

Appl. No.:

09/020065

Inventors:

Robert Martin Townsend - Boothwyn PA
Robert Korngold - Cherry Hill NJ

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3812

US Classification:

530317, 530300, 514 9, 514 11

Abstract:

Peptides which mimic a loop on the -chain that either interact with a cytokine or a -chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.

US Patent:

7510844, Mar 31, 2009

Filed:

Jan 22, 2007

Appl. No.:

11/656206

Inventors:

Robert M. Townsend - Boothwyn PA, US
Catherine A. Fleener - Holland PA, US
Francisco Leon - Bethesda MD, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.

US Patent:

20020039577, Apr 4, 2002

Filed:

Jun 8, 2001

Appl. No.:

09/877987

Inventors:

Robert Townsend - Boothwyn PA, US
Charles Todderud - Newton PA, US
Robert Peach - San Diego CA, US

International Classification:

A61K039/395

US Classification:

424/131100

Abstract:

The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.

US Patent:

20040092709, May 13, 2004

Filed:

Jun 29, 2001

Appl. No.:

09/896784

Inventors:

Robert Townsend - Boothwyn PA, US
Robert Korngold - Cherry Hill NJ, US
Swati Choksi - Broomal PA, US

Assignee:

Thomas Jefferson University

International Classification:

C07K007/08
C07K007/06

US Classification:

530/328000, 530/329000

Abstract:

Peptides which mimic a loop on the -chain that either interact with a cytokine or a -chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.