Robert S Townsend

US Patent:

6869956, Mar 22, 2005

Filed:

Feb 1, 2002

Appl. No.:

10/062847

Inventors:

James R. Burke - Holland PA, US
Robert M. Townsend - Boothwyn PA, US
Yuping Qiu - Windsor CT, US
Fred Christopher Zusi - Hamden CT, US
Steven G. Nadler - Boothwyn PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61P001/00
A61P011/06
A61P019/02
A61P037/06
C07D487/04

US Classification:

514250

Abstract:

The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.

US Patent:

8378082, Feb 19, 2013

Filed:

Jan 7, 2009

Appl. No.:

12/319442

Inventors:

Catherine Aversa Fleener - Holland PA, US
Robert M. Townsend - Boothwyn PA, US
Francisco Leon - Bethesda MD, US

International Classification:

C07K 16/28
C12N 5/12

US Classification:

5303882, 435346

Abstract:

The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.

US Patent:

53160401, May 31, 1994

Filed:

Mar 26, 1993

Appl. No.:

8/037437

Inventors:

Robert L. Townsend - Clifton VA
Alfred G. Downs - Bluemont VA

International Classification:

F16K 3700
F16L 500

US Classification:

137556

Abstract:

A valve alignment tool for correctly aligning the valve box above each shut off valve in the water pipes of a underground water main. The valve alignment tool fits over the square stem nut of the gate valve, and fits in sliding engagement with the valve box to align the bottom of the valve box around the square stem nut of the gate valve. The top of the valve alignment tool protrudes above the surface of the ground and contains a bubble level so that it can be held vertically as the sections the valve box are slid down the outside of the valve alignment tool. When the trench around the underground water main has been filled in, and the top section of the valve box has been put in place, the valve alignment tool is withdrawn.

US Patent:

20160153990, Jun 2, 2016

Filed:

Mar 27, 2014

Appl. No.:

14/779204

Inventors:

- Princeton NJ, US
Jaclyn Rae - Durham, DE
Robert M. Townsend - Princeton NJ, US

International Classification:

G01N 33/569

Abstract:

The present invention provides methods utilizing changes in CD4+CD57+ T cells levels for determining the susceptibility of a transplant patient or patient in need thereof to costimulation blockade resistant rejection. These methods are useful for identifying effective drug regimens for the treatment of immune disorders associated with graft transplantation and/or maintenance of a transplant.