Robert J Townsend

US Patent:

6346602, Feb 12, 2002

Filed:

Feb 6, 1998

Appl. No.:

09/020065

Inventors:

Robert Martin Townsend - Boothwyn PA
Robert Korngold - Cherry Hill NJ

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3812

US Classification:

530317, 530300, 514 9, 514 11

Abstract:

Peptides which mimic a loop on the -chain that either interact with a cytokine or a -chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.

US Patent:

7510844, Mar 31, 2009

Filed:

Jan 22, 2007

Appl. No.:

11/656206

Inventors:

Robert M. Townsend - Boothwyn PA, US
Catherine A. Fleener - Holland PA, US
Francisco Leon - Bethesda MD, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.

US Patent:

20020039577, Apr 4, 2002

Filed:

Jun 8, 2001

Appl. No.:

09/877987

Inventors:

Robert Townsend - Boothwyn PA, US
Charles Todderud - Newton PA, US
Robert Peach - San Diego CA, US

International Classification:

A61K039/395

US Classification:

424/131100

Abstract:

The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.

US Patent:

20040092709, May 13, 2004

Filed:

Jun 29, 2001

Appl. No.:

09/896784

Inventors:

Robert Townsend - Boothwyn PA, US
Robert Korngold - Cherry Hill NJ, US
Swati Choksi - Broomal PA, US

Assignee:

Thomas Jefferson University

International Classification:

C07K007/08
C07K007/06

US Classification:

530/328000, 530/329000

Abstract:

Peptides which mimic a loop on the -chain that either interact with a cytokine or a -chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a -chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.

US Patent:

41640551, Aug 14, 1979

Filed:

Nov 21, 1977

Appl. No.:

5/853747

Inventors:

Robert L. Townsend - Irvine CA

Assignee:

Purex Corporation - Lakewood CA

International Classification:

A47L 700

US Classification:

15321

Abstract:

Suction and germicidal spray producing apparatus effects rapid removal of soils and bacteria from hard surface floors in both dry and wet states, the removed dry and wet soils and bacteria being isolated and confined; the apparatus includes a head assembly carrying longitudinally spaced, resiliently flexible strips extending in parallel relation to engage the floor surface, the head assembly including support means to engage the floor surface; means is provided for applying suction to the space between the strips; and means is provided for applying cleaning liquid to the floor surface to wet that surface visibly and openly outside the space between the strips, so that the user moving the head assembly back and forth can controllably move the head and strips over the surface to assure suction removal of liquid, soils and bacteria on the floor surface, to be conducted away from the head assembly.

US Patent:

40172023, Apr 12, 1977

Filed:

Oct 20, 1975

Appl. No.:

5/624224

Inventors:

Robert E. Townsend - Temple City CA

International Classification:

B23B 5100

US Classification:

408226

Abstract:

A boring tool with a variable length extension formed by a standard piece of pipe, for particular use in drilling downwardly from a wall studding header and through a fire brake bracing member which extends between the wall studs below the header, to facilitate the installation of piping, electric conduits, and the like, wherein a standard piece of pipe is threadedly connected by a coupling member at one end to a first shank portion of a boring tool, and a coupling member at its opposite end to an axially aligned second shank adapted for connection with a driving instrumentality. The coupling member in a modified form is provided at its pipe connection end with internally stepped threaded portions for selective connection with the ends of pipes of different diameter.

US Patent:

41585755, Jun 19, 1979

Filed:

Apr 11, 1977

Appl. No.:

5/786352

Inventors:

Robert L. Townsend - Irvine CA

Assignee:

Purex Corporation - Lakewood CA

International Classification:

B08B 504
B08B 704

US Classification:

134 6

Abstract:

Soils and bacteria are removed from a hard floor surface by providing two resiliently flexible, transversely parallel strips, applying suction to the space between the strips so that their lower edge portions engage the floor surface, bodily displacing the strips longitudinally back and forth, while applying disinfectant or cleaning liquid to the floor surface outside the space between the strips to wet that surface over which the strips are displaced and flex back and forth.