Robert A Webb

US Patent:

6341036, Jan 22, 2002

Filed:

Aug 24, 2000

Appl. No.:

09/622971

Inventors:

Guillermo J. Tearney - Cambridge MA
Brett E. Bouma - Quincy MA
Robert H. Webb - Lincoln MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 2100

US Classification:

359368, 359209

Abstract:

A scanning confocal microscopy system, especially useful for endoscopy with a flexible probe which is connected to the end of an optical fiber( ). The probe has a grating( ) and a lens( ) which delivers a beam of multi-spectral light having spectral components which extend in one dimension across a region of an object and which is moved to scan in another dimension. The reflected confocal spectrum is measured to provide an image of the region.

US Patent:

6399936, Jun 4, 2002

Filed:

Sep 28, 1999

Appl. No.:

09/407458

Inventors:

Zhijiang Hang - Lexington MA
Victor Lazarev - Burlington MA
Robert H. Webb - Lincoln MA

Assignee:

New Dimension Research Instrument, Inc. - Woburn MA

International Classification:

H01J 314

US Classification:

250216, 2502081, 257 82

Abstract:

A confocal scanning imaging device for viewing an object includes an array of independently addressable microlasers and an array of detectors for detecting light from an object to which light from the microlasers has been directed. The array of microlasers and the array of detectors are combined into a single array, such as on a single chip, and in a pattern constructed and arranged so that different detectors are adjacent to each microlaser so that light from an illuminated object may be directed back to the vicinity of the illuminating microlaser and be detected by the adjacent detector(s). An optical arrangement directs light generated by the microlasers onto an object and directs light from an object so illuminated onto detectors adjacent to the illuminating microlaser. The optical arrangement includes a bilens and a matching lens system including two objective lenses. A microlens of pitch substantially identical to the pitch of the microlaser array collimates light generated by the microlasers.

US Patent:

6486943, Nov 26, 2002

Filed:

Sep 19, 2000

Appl. No.:

09/664640

Inventors:

Stephen A. Burns - Reading MA
Robert H. Webb - Lincoln MA

Assignee:

The Schepens Eye Research Institute, Inc. - Boston MA

International Classification:

G01B 900

US Classification:

356124, 356127

Abstract:

The invention relates to methods and apparatus for determining a characteristic of an optical element. The apparatus includes a spatial light pattern generator adapted to generate a beam of light at a predetermined spatial position, at least one lenslet disposed in an array of lenslets adapted to receive the beam of light from the spatial light pattern generator, and to direct the beam of light to the optical element. The apparatus further includes a detector positioned to receive the beam of light subsequent to the beam of light encountering the optical element. The detector is adapted to detect a received spatial position at which the detector receives the beam of light. The apparatus also includes a processor adapted to compare the predetermined spatial position with the received spatial position to determine the characteristic of the optical element. The invention further relates to methods and apparatus for generating a diffraction limited image. The apparatus includes a spatial light pattern generator adapted to generate a plurality of beams of light at selected spatial positions to compensate for a characteristic of an optical element and an array of lenslets adapted to receive the plurality of beams of light from the spatial light pattern generator and to direct the plurality of beams of light to the optical element.

US Patent:

6640124, Oct 28, 2003

Filed:

Jul 31, 2001

Appl. No.:

09/919498

Inventors:

Ann E. Elsner - Reading MA
Stephen A. Burns - Reading MA
Andreas W. Dreher - Escondido CA
Robert H. Webb - Lincoln MA

Assignee:

The Schepens Eye Research Institute - Boston MA

International Classification:

A61B 505

US Classification:

600407, 600473, 600476, 356342, 351221

Abstract:

An apparatus and a method are disclosed for separating light remitted by a target into a directly scattered light component and at least one multiply scattered light component, detecting the components at least substantially simultaneously, and forming independent sets of image information from each component. The apparatus and the method can be employed in conjunction with techniques such as scanning and tomography to attain precise imaging of biological tissue, including the retina of the eye.

US Patent:

6664241, Dec 16, 2003

Filed:

May 29, 2001

Appl. No.:

09/870071

Inventors:

Conway C. Chang - Cambridge MA
Binh T. Dang - San Jose CA
Christopher J. Baldwin - Santa Cruz CA
David J. Loury - San Jose CA
Reyna J. Simon - Los Gatos CA
Robert R. Webb - Moss Beach CA

Assignee:

Micrologix Biotech Inc. - Vancouver

International Classification:

A61K 3170

US Classification:

514 31, 536 71

Abstract:

The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.

US Patent:

6747795, Jun 8, 2004

Filed:

Jun 20, 2001

Appl. No.:

09/885576

Inventors:

Charles P. Lin - Arlington MA
Robert H. Webb - Lincoln MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 2106

US Classification:

359385, 385116, 600182

Abstract:

A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected remitted light to the original line. Fibers, not confocal with the illumination, carry light to be rejected from the image back on itself upon double passing, while separate fibers carry light from non-confocal sample planes. The transformation allows efficient rejection of unwanted photons at a slit aperture. The fiber bundle and an objective lens provide a flexible probe for imaging internal tissue for pathological examination on a cellular level.

US Patent:

6831781, Dec 14, 2004

Filed:

Nov 29, 2001

Appl. No.:

09/999182

Inventors:

Guillermo J. Tearney - Cambridge MA
Brett E. Bouma - Quincy MA
Robert H. Webb - Lincoln MA
Constantinos Pitris - Nicosia, CY
Millen Shishkov - Newline Ruse, BG

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 2106

US Classification:

359385, 359368

Abstract:

A scanning confocal microscopy system and apparatus, especially useful for endoscopy with a flexible probe which is connected to the end of an optical fiber ( ). The probe has a grating ( ) and a lens ( ) which delivers a beam of multi-spectral light having spectral components which extend in one dimension across a region of an object and which is moved to scan in another dimension. The reflected confocal spectrum is measured to provide an image of the region.

US Patent:

7129455, Oct 31, 2006

Filed:

Nov 6, 2003

Appl. No.:

10/702708

Inventors:

Robert H. Webb - Lincoln MA, US
Clara E. Dimas - Malden MA, US

Assignee:

Boston Micromachines Corporation - Watertown MA

International Classification:

G01J 1/20

US Classification:

2502019, 250216

Abstract:

A system and method modifying wavefront shape is provided. Generally, the system contains a wavefront shape modifying device for modifying the shape of the wavefront. The system also contains a series of optical devices for returning the modified wavefront to the wavefront modifying device with an orientation that enables further modification of the modified wavefront by the wavefront modifying device. The method contains the steps of: reflecting a wavefront from a surface of a wavefront shape modifying device, resulting in the wavefront having a modified shape; and reflecting the wavefront having a modified shape from the surface of the wavefront shape modifying device a second time resulting in a final wavefront having a shape that has been modified twice.