Robert Neil Weiss

US Patent:

20120083767, Apr 5, 2012

Filed:

Oct 3, 2011

Appl. No.:

13/251910

Inventors:

Gary Gerstenblith - Reisterstown MD, US
Jason Benkoski - Ellicott City MD, US
Jeffrey Brinker - Baltimore MD, US
George Coles - Baltimore MD, US
Chao-Wei Hwang - Ellicott City MD, US
Peter Johnston - Baltimore MD, US
Gordon Tomaselli - Lutherville MD, US
Robert G. Weiss - Hunt Valley MD, US
Steven P. Schulman - Reisterstown MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61M 5/00

US Classification:

6048901

Abstract:

An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.

US Patent:

20200297474, Sep 24, 2020

Filed:

Oct 5, 2018

Appl. No.:

16/753567

Inventors:

- Baltimore MD, US
Peter Johnston - Baltimore MD, US
Gary Gerstenblith - Reisterstown MD, US
Robert G. Weiss - Hunt Valley MD, US
Gordon Tomaselli - Baltimore MD, US
Steven Schulman - Reisterstown MD, US

International Classification:

A61F 2/02
A61K 47/38
A61K 35/28
A61K 9/16
A61K 35/33
A61K 47/34
A61M 39/02
A61K 47/36
A61K 38/39
A61K 9/06
A61L 29/16
A61L 27/54
A61L 27/52
A61L 27/56
A61L 27/48
A61L 27/38
A61L 27/34
A61L 27/26

Abstract:

The present invention provides an implantable bioreactor comprising cells enclosed within an enclosure, said cells being capable of producing paracrine factors, wherein the enclosure is collapsible or expandable or both or neither, wherein the enclosure is semipermeable such that it provides containment of the cells preventing the egress of the cells while further providing a barrier that shields the cells from immunological attack, and wherein the enclosure is permeable to the entire secretome of the cell including exosomes, nucleic acids and proteins. The implantable bioreactor can have various configurations and can house internally a cell culture matrix than can include hydrogels, microbeads, and nanofiber matrices along with other active agents.

US Patent:

20190314416, Oct 17, 2019

Filed:

Feb 21, 2019

Appl. No.:

16/281620

Inventors:

- Baltimore MD, US
Jason Benkoski - Ellicott City MD, US
George Coles - Baltimore MD, US
Chao-Wei Hwang - Ellicott City MD, US
Peter Johnston - Baltimore MD, US
Gordon Tomaselli - Lutherville MD, US
Robert G. Weiss - Hunt Valley MD, US
Steven P. Schulman - Reisterstown MD, US

International Classification:

A61K 35/28
A61L 31/14
A61L 31/10
A61K 9/00
A61L 29/14
A61L 29/16
A61L 31/16

Abstract:

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

US Patent:

20170245976, Aug 31, 2017

Filed:

Mar 23, 2017

Appl. No.:

15/467455

Inventors:

- Baltimore MD, US
Jason Benkoski - Ellicott City MD, US
Jeffrey Brinker - Baltimore MD, US
George Coles - Baltimore MD, US
Chao-Wei Hwang - Ellicott City MD, US
Peter Johnston - Baltimore MD, US
Gordon Tomaselli - Lutherville MD, US
Robert G. Weiss - Hunt Valley MD, US
Steven P. Schulman - Reisterstown MD, US

International Classification:

A61F 2/02
A61L 27/56
A61K 35/545
A61L 27/28
A61L 27/54
A61L 27/16
A61L 27/38
A61L 29/00

Abstract:

An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.

US Patent:

20160235956, Aug 18, 2016

Filed:

Oct 7, 2014

Appl. No.:

15/025902

Inventors:

Chao-Wei HWANG - West Friendship MD, US
Zhiyong XIA - Rockville MD, US
Virginia E. BOGDAN - Owings Mills MD, US
Jeffrey A. BRINKER - Baltimore MD, US
Gary GERSTENBLITH - Reisterstown MD, US
Peter V. JOHNSTON - Baltimore MD, US
Steven SCHULMAN - Baltimore MD, US
Gorden TOMASELLI - Baltimore MD, US
Robert WEISS - Cockeysville MD, US
- Baltimore MD, US

International Classification:

A61M 37/00
A61L 33/08
A61L 33/00
A61L 31/00
A61F 2/04
A61L 31/14
A61L 27/56
A61L 27/54
A61L 27/38
A61L 27/18
A61L 31/10
A61L 31/16

Abstract:

Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

US Patent:

20150217030, Aug 6, 2015

Filed:

Feb 5, 2015

Appl. No.:

14/614432

Inventors:

- Baltimore MD, US
Peter V. Johnston - Baltimore MD, US
Chao-Wei Hwang - West Friendship MD, US
Gary Gerstenblith - Reisterstown MD, US
Robert G. Weiss - Cockeysville MD, US
Gordon Tomaselli - Lutherville MD, US
Steven P. Schulman - Baltimore MD, US
Jeffrey A. Brinker - Baltimore MD, US

International Classification:

A61L 31/10
A61L 31/14
A61L 31/16
B05D 1/18

Abstract:

Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.