Robert Edward Weiss

US Patent:

7524316, Apr 28, 2009

Filed:

Nov 4, 2004

Appl. No.:

10/982504

Inventors:

David R. Hennings - Roseville CA, US
Mitchel P. Goldman - La Jolla CA, US
Robert A. Weiss - Hunt Valley MD, US
Eric B. Taylor - Roseville CA, US
Don Johnson - Roseville CA, US
Ignacio Cespedes - Folsom CA, US

Assignee:

CoolTouch, Inc. - Roseville CA

International Classification:

A61B 18/18

US Classification:

606 7, 606 3, 606 15, 607 88, 607 89, 128898

Abstract:

This invention is an improved method and device for treating varicose veins or the greater saphenous vein. The method comprises the use of infrared laser radiation in the region of 1. 2 to 2. 2 um in a manner from inside the vessel or such that the endothelial cells of the vessel wall are damaged and collagen fibers in the vessel wall are heated to the point where they permanently contract, the vessel or is occluded and ultimately resorbed. The device includes a laser delivered via a fiber optic catheter that may have frosted or diffusing fiber tips , or that may be provided with a protective spacer. A motorized pull back device may be used, and a thermal sensor may be used to help control the power required to maintain the proper treatment temperature.

US Patent:

7921854, Apr 12, 2011

Filed:

Nov 22, 2006

Appl. No.:

11/562944

Inventors:

David R. Hennings - Roseville CA, US
Mitchel P. Goldman - San Diego CA, US
Robert A. Weiss - Hunt Valley MD, US
Eric B. Taylor - Roseville CA, US
Don Johnson - Roseville CA, US

Assignee:

CoolTouch Incorporated - Roseville CA

International Classification:

A61B 19/00

US Classification:

128898, 606 3, 606 7, 606 15, 607 88, 607 89

Abstract:

Improved devices and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.

US Patent:

8448644, May 28, 2013

Filed:

Oct 30, 2007

Appl. No.:

11/928624

Inventors:

David R. Hennings - Roseville CA, US
David J. Fullmer - Roseville CA, US
Craig Lindsay - Roseville CA, US
Eric B. Taylor - Roseville CA, US
Robert A. Weiss - Hunt Valley MD, US

Assignee:

CoolTouch Incorporated - Roseville CA

International Classification:

A61B 19/00
A61B 18/18
A61N 5/06

US Classification:

128898, 606 3, 606 15, 607 89

Abstract:

A device and method to improve the ultrasound visibility of a catheter placed inside the body is described. The catheter is sonically vibrated by an external driver device that transmits the acoustic vibration down the catheter and inside the body. An ultrasound transducer is used to pick up the ultrasound vibrations directly or detects the sonic vibrations using a Doppler mode ultrasound machine.

US Patent:

20030139469, Jul 24, 2003

Filed:

Jan 23, 2002

Appl. No.:

10/056284

Inventors:

Robert Weiss - Vacaville CA, US
Bruce Hammock - Davis CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K031/335
A61K031/17
A61K031/13
A61K031/045

US Classification:

514/475000, 514/588000, 514/685000, 514/727000, 514/579000

Abstract:

The present invention provides methods of slowing or inhibiting vascular smooth muscle (VSM) cell proliferation to slow the development or recurrence of atherosclerosis by contacting VSM cells with soluble epoxide hydrolase (sEH) inhibitors. Further, the methods of the invention can be used to slow or to inhibit vascular restenosis after angioplasty and the stenosis of vascular stents. Further, the methods of the invention can be used to slow or to inhibit the stenosis of hemodialysis grafts and other natural and synthetic vascular grafts.

US Patent:

20030144236, Jul 31, 2003

Filed:

Sep 26, 2002

Appl. No.:

10/240140

Inventors:

Robert Weiss - Vacaville CA, US

International Classification:

A61K048/00
A61K039/395

US Classification:

514/044000, 424/146100

Abstract:

Methods and compositions for regulating abnormal cell growth and proliferation mediated by p21using inhibitors of p21.

US Patent:

20040092913, May 13, 2004

Filed:

Oct 30, 2003

Appl. No.:

10/699212

Inventors:

David Hennings - Roseville CA, US
Mitchell Goldman - La Jolla CA, US
Robert Weiss - Hunt Valley MD, US
Eric Taylor - Roseville CA, US
Don Johnson - Roseville CA, US

International Classification:

A61B018/24

US Classification:

606/003000, 606/009000, 606/015000

Abstract:

This invention is an improved method and device for treating varicose veins or the greater saphenous vein . The method comprises the use of infrared laser radiation in the region of 1.2 to 1.8 um in a manner from inside the vessel or such that the endothelial cells of the vessel wall are damaged and collagen fibers in the vessel wall are heated to the point where they permanently contract, the vessel or is occluded and ultimately resorbed. The device includes a laser delivered via a fiber optic catheter that may have frosted or diffusing fiber tips . A motorized pull back device is used, and a thermal sensor may be used to help control the power required to maintain the proper treatment temperature.

US Patent:

20050043262, Feb 24, 2005

Filed:

Jun 14, 2004

Appl. No.:

10/867951

Inventors:

Robert Weiss - Vacaville CA, US

International Classification:

A61K048/00
A61K039/395

US Classification:

514044000, 424146100

Abstract:

The present invention provides methods and compositions for regulating abnormal cell growth and proliferation mediated by p21using inhibitors of p21.

US Patent:

20100042085, Feb 18, 2010

Filed:

Oct 23, 2009

Appl. No.:

12/604815

Inventors:

David R. Hennings - Roseville CA, US
Mitchel P. Goldman - La Jolla CA, US
Robert A. Weiss - Hunt Valley MD, US
Eric B. Taylor - Roseville CA, US
Don Johnson - Roseville CA, US

International Classification:

A61B 18/24

US Classification:

606 15

Abstract:

This invention is an improved method and device for treating varicose veins or the greater saphenous vein The method comprises the use of infrared laser radiation in the region of 1.2 to 1.8 um in a manner from inside the vessel or such that the endothelial cells of the vessel wall are damaged and collagen fibers in the vessel wall are heated to the point where they permanently contract, the vessel or is occluded and ultimately resorbed. The device includes a laser delivered via a fiber optic catheter that may have frosted or diffusing fiber tips A motorized pull-back device is used, and a thermal sensor may be used to help control the power required to maintain the proper treatment temperature.