Roberta Jo Greco

US Patent:

20040229247, Nov 18, 2004

Filed:

Jan 23, 2004

Appl. No.:

10/763597

Inventors:

Charles DeBoer - Palmyra NY, US
Roberta Greco - Canandaigua NY, US
John Noonan - Rochester NY, US
Richard Murante - Henrietta N, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/025300, 205/777500

Abstract:

The present invention relates to methods of metallizing nucleic acid molecules and to methods of attaching nucleic acid molecules to conductive surfaces. Methods of detecting target nucleic acid molecules based on these techniques are also disclosed.

US Patent:

20060019273, Jan 26, 2006

Filed:

May 12, 2005

Appl. No.:

11/128079

Inventors:

Dennis Connolly - Rochester NY, US
Jeffrey Hainon - Webster NY, US
Richard Murante - Rochester NY, US
Roberta Greco - Canandaigua NY, US
Craig Tiller - Rochester NY, US

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435006000, 435287200

Abstract:

The present invention relates to a detection card made of a first planar element having a detection chip. The detection chip has two or more electrically separated conductors fabricated on a substrate and capture probes attached to the conductors, such that a gap exists between the capture probes on the conductors. A sample, potentially containing a target molecule, can be analyzed for the presence of the target molecule by determining whether the conductors are electrically connected. The detection card also has a second planar element parallel to and joined with the first planar element along a first planar interface. A fluid pathway is formed proximate to the first planar interface and includes a detection reservoir into which at least part of the detection chip is received. Also disclosed is a system and a method for detecting a target molecule, both of which utilize the detection card.

US Patent:

20060024702, Feb 2, 2006

Filed:

May 12, 2005

Appl. No.:

11/128078

Inventors:

Dennis Connolly - Rochester NY, US
Jeffrey Hainon - Webster NY, US
Scott Seabridge - Penfield NY, US
Roberta Greco - Canandaigua NY, US

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435006000, 435287200

Abstract:

The present invention relates to a device suitable for detecting a target molecule in a sample using a detection card having two or more electrically separated conductors, wherein the sample can be analyzed for the presence of the target molecule by determining whether the conductors are electrically connected. The device has a platform for receiving the detection card and a lid moveable from a first position in engagement with the platform and a second position distal from the platform. The lid has a fluid interface suitable for establishing fluid communication between the device and the detection card and an electrical interface suitable for establishing electrical communication between the device and the detection card. Also disclosed is a system and a method for detecting a target molecule, both of which utilize the device.