Jeffrey Smith - Del Mar CA, US Robyn Richardson - San Diego CA, US
International Classification:
A61K 31/202
US Classification:
514560000
Abstract:
The present invention provides for compounds of formula (I)-(XIII), as well as pharmaceutically acceptable salts thereof, metabolites thereof, pro-drugs thereof, and pharmaceutical kits that include such compounds. The present invention also provides for the compounds of formula (I)-(XIII) for use in medical therapy or diagnosis. The present invention also provides for the use of the compounds of formula (I)-(XIII) in treating cancer in mammals (e.g., humans), as well inhibiting tumor cell growth in such mammals. The present invention also provides for methods of inhibiting FAS. The methods include contacting FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of inhibiting the TE domain of the FAS. The methods include contacting the thioesterase TE domain of the FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of treating cancer in mammals, as well as methods of inhibiting tumor cell growth in such mammals. The methods include administering a compound of formula (I)-(XIII) to a mammal in need of such treatment.
Novel Belactosin Derivatives As Therapeutic Agents/Biological Probes And Their Synthesis
Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.
Novel Antagonists Of The Human Fatty Acid Synthase Thioesterase
The present invention provides for compounds of formula (I)-(XIII), as well as pharmaceutically acceptable salts thereof, metabolites thereof, pro-drugs thereof, and pharmaceutical kits that include such compounds. The present invention also provides for the compounds of formula (I)-(XIII) for use in medical therapy or diagnosis. The present invention also provides for the use of the compounds of formula (I)-(XIII) in treating cancer in mammals (e.g., humans), as well inhibiting tumor cell growth in such mammals. The present invention also provides for methods of inhibiting FAS. The methods include contacting FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of inhibiting the TE domain of the FAS. The methods include contacting the thioesterase TE domain of the FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of treating cancer in mammals, as well as methods of inhibiting tumor cell growth in such mammals. The methods include administering a compound of formula (I)-(XIII) to a mammal in need of such treatment.
Bi-Specific Binding Agents Targeting Syndecan-1 And Fibroblast Growth Factor Receptor
- Osaka-Shi, Osaka, JP Robyn RICHARDSON - San Diego CA, US Anjuli TIMMER - San Diego CA, US Roland NEWMAN - San Diego CA, US Marco GYMNOPOULOS - San Diego CA, US
International Classification:
A61K 47/68 C07K 16/28
Abstract:
Presented herein, in certain embodiments, are bi-specific binding agents comprising an antibody portion that binds specifically to syndecan-1 and a Fynomer portion that binds specifically to a Fibroblast Growth Factor Receptor 3 (FGFR3), compositions thereof and uses thereof for treating a neoplasm.
Syndecan-1 (Cd138) Binding Agents And Uses Thereof
Elon College Elementary School Elon College NC 1960-1964, Western Middle School Elon College NC 1964-1968, Gibsonville High School Gibsonville NC 1968-1972
Community:
Glenda Ingle, Kenneth Smith, Penny Pettigrew, Kathy Gillispie, Donna Cook, Vicki Overman, Linda Baldwin, Debbie Reeves, Pamela Sears, Bitsy Lewis, James Smith, Bobby Swanger