Roger C Olewinski from East Brunswick, NJ, age 59

Conversion Of Indene To (1S)-Amino-(2R)-Indanol Free Of Any Stereoisomer, By Combination Of Dioxygenase Bioconversion And Chemical Steps
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US Patent:

58587373, Jan 12, 1999
Filed:

Aug 14, 1996
Appl. No.:

8/696667
Inventors:

Barry C. Buckland - Westfield NJ
Neal C. Connors - Fanwood NJ
Michel M. Chartrain - Westfield NJ
Francis P. Gailliot - Cranford NJ
Randolph L. Greasham - Mountainside NJ
Barbara Jackey - Bloomfield NJ
Brian Heimbuch - North Brunswick NJ
Chanyong Lee - Princeton NJ
Roger C. Olewinski - Milltown NJ
F. Edward Roberts - Princeton NJ
Paul J. Reider - Westfield NJ
Thomas R. Verhoeven - Cranford NJ
Chris H. Senanayake - North Brunswick NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C12P 1302
C12P 722
C12P 4100
US Classification:

435129
Abstract:

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp. , followed by various chemical step(s), e. g. , chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.