Roger Allen Whiting

US Patent:

57338710, Mar 31, 1998

Filed:

Mar 16, 1995

Appl. No.:

8/030429

Inventors:

Brian J. Alps - Linlithgow, GB6
Christine Mary Brown - Glasgow, GB6
Franklin D. Collins - Agoura Hills CA
Caroline J. Emmett - Belmont CA
Michael Spedding - Le Vesinet, FR
Deborah Russell - Boulder CO
Seth P. Finklestein - Needham MA
Michael A. Moskowitz - Belmont MA
Roger Lewis Whiting - Los Altos CA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 3800
A61K 3827
A61K 3816
A61K 3828

US Classification:

514 12

Abstract:

Intravenous administration and pharmaceutically acceptable compositions of neurotrophic factors for treating neuronal damage in the central nervous system of individuals in need of such treatment are disclosed. The neuronal damage associated with ischemia, hypoxia, or neurodegeneration may result from stroke or cardiac arrest. This invention provides for the intravenous administration of neurotrophic factors such as bFGF, aFGF, NGF, CNTF, BDNF, NT3, NT4, IGF-I and IGF-II.