Roland James Roy

US Patent:

20130310911, Nov 21, 2013

Filed:

Jul 19, 2013

Appl. No.:

13/946338

Inventors:

Damien Craig Rodger - South Pasadena CA, US
Andy Fong - Los Angeles CA, US
Victor Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Yury Gerasimenko - Los Angeles CA, US
Igor Lavrov - Rancho Palos Verdes CA, US
Susan J. Harkema - Louisville KY, US
Claudia A. Angeli - Louisville KY, US

Assignee:

California Institute of Technology - Pasadena CA
University of Louisville Research Foundation, Inc. - Louisville KY
The Regents of the University of California - Oakland CA

International Classification:

A61N 1/05

US Classification:

607117, 427 21, 216 17

Abstract:

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.

US Patent:

20220313993, Oct 6, 2022

Filed:

Jun 10, 2022

Appl. No.:

17/837913

Inventors:

- Oakland CA, US
Victor Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Daniel C. Lu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 1/36
A61K 31/00
A61K 31/197
A61N 1/04
G16H 20/40

Abstract:

In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.

US Patent:

20210378991, Dec 9, 2021

Filed:

Aug 19, 2021

Appl. No.:

17/407043

Inventors:

- Oakland CA, US
V. Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Yury P. Gerasimenko - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/137
A61N 1/05
A61N 1/36
A61K 31/4168
A61K 31/4178
A61K 31/496
A61K 31/4985
A61K 31/506
A61K 31/517
A61K 31/527

Abstract:

In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

US Patent:

20190167987, Jun 6, 2019

Filed:

Nov 26, 2018

Appl. No.:

16/200467

Inventors:

- Oakland CA, US
V. Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Yury P. Gerasimenko - Los Angeles CA, US

International Classification:

A61N 1/36
A61K 31/517
A61K 31/506
A61K 31/4985
A61K 31/496
A61K 31/4178
A61K 31/527
A61K 31/137
A61N 1/05
A61K 31/4168

Abstract:

In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

US Patent:

20180361146, Dec 20, 2018

Filed:

May 9, 2018

Appl. No.:

15/975678

Inventors:

- Oakland CA, US
Victor Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Daniel C. Lu - Los Angeles CA, US

International Classification:

A61N 1/36
A61K 31/197
A61K 31/00
A61N 1/04
G16H 20/40

Abstract:

In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.

US Patent:

20180229038, Aug 16, 2018

Filed:

Mar 29, 2018

Appl. No.:

15/940473

Inventors:

- Pasadena CA, US
- Louisville KY, US
- Oakland CA, US
Robert S. Keynton - Louisville KY, US
Victor Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Yury Gerasimenko - Los Angeles CA, US
Susan J. Harkema - Louisville KY, US
Jonathan Hodes - Louisville KY, US
Claudia A. Angeli - Louisville KY, US
Mandheerej S. Nandra - Pasadena CA, US
Thomas Anthony Desautels - Pasadena CA, US
Steven L. Upchurch - Louisville KY, US
Douglas J. Jackson - New Albany IN, US
Yangsheng Chen - Louisville KY, US

International Classification:

A61N 1/36
A61N 1/05
A61B 5/00
A61B 5/11
A61B 5/0492

Abstract:

Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.

US Patent:

20170274209, Sep 28, 2017

Filed:

Aug 21, 2015

Appl. No.:

15/505053

Inventors:

- Oakland CA, US
Parag Gad - Woodland Hills CA, US
Roland R. Roy - Playa Vista CA, US
Yury P. Gerasimenko - Los Angeles CA, US
Daniel C. Lu - Los Angeles CA, US
Hui Zhong - Monterey Park CA, US

International Classification:

A61N 1/36
A61K 31/475
A61H 3/00
A61K 31/496
A63B 22/02
A63B 21/06

Abstract:

In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the Lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying. In certain embodiments the electrical stimulation is at a frequency and intensity sufficient to improve the amount of bladder emptying (e.g., to provide at least 30% emptying or at least 40% emptying, or at least 50% emptying, or at least 60% emptying, or at least 70% emptying, or at least 80% emptying, or at least 90% emptying, or at least 95% emptying.

US Patent:

20170157389, Jun 8, 2017

Filed:

Aug 9, 2016

Appl. No.:

15/232623

Inventors:

- Pasadena CA, US
- Oakland CA, US
- Louisville KY, US
Damien Craig Rodger - South Pasadena CA, US
Andy Fong - Los Angeles CA, US
Victor Reggie Edgerton - Los Angeles CA, US
Roland R. Roy - Playa Vista CA, US
Yury Gerasimenko - Los Angeles CA, US
Igor Lavrov - Rancho Palos Verdes CA, US
Susan J. Harkema - Louisville KY, US
Claudia A. Angeli - Louisville KY, US

International Classification:

A61N 1/05

Abstract:

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.