Ronald Charles Conaway

US Patent:

6379923, Apr 30, 2002

Filed:

Jul 29, 1999

Appl. No.:

09/362871

Inventors:

D. Roxanne Duan - Bethesda MD
Joan W. Conaway - Oklahoma City OK
Ronald C. Conaway - Oklahoma City OK

Assignee:

Human Genome Sciences, Inc. - Rockville MD
Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C12N 1563

US Classification:

435 691, 530350

Abstract:

ELL2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ELL2 polypeptides and polynucleotides in the design of protocols for the treatment of neoplastic disorders, among others and diagnostic assays for such conditions.

US Patent:

6858709, Feb 22, 2005

Filed:

Feb 25, 2000

Appl. No.:

09/914324

Inventors:

Joan W. Conaway - Kansas City MO, US
Ronald C. Conaway - Kansas City MO, US
Takumi Kamura - Fukuoka, JP

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C07K001/10
C07K001/00

US Classification:

530350, 530835, 530828

Abstract:

Rbx1, an evolutionarily conserved Cullin-interacting RING-H2 finger protein, has been discovered. Mammalian Rbx1 has been identified as a component of the CUL2-containing VHL complex. An Rbx1 homolog from has also been identified as a subunit and activator of the Cdc53-containing SCFubiquitin ligase required for ubiquitination of the cdk inhibitor Sic1 and for the G1/S cell cycle transition in yeast, providing a link between the multiprotein VHL tumor suppressor complex and cellular ubiquitination. The Rbx1 protein acts as a cellular marker useful (1) in detecting a possible predisposition to certain carcinomas, (2) as a molecular target for treating those carcinomas therapeutically. (3) as a target for inhibition by drugs that manipulate the growth of cells, and (4) as a research tool to better understand the various complex mechanisms of cell ubiquitination, binding of certain activator proteins, fibronectin deposition and other aspects of the cellular division process.

US Patent:

20050019813, Jan 27, 2005

Filed:

Aug 5, 2004

Appl. No.:

10/913937

Inventors:

Joan Conaway - Kansas City MO, US
Ronald Conaway - Kansas City MO, US
Takumi Kamura - Fukuoka, JP

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C12N009/64

US Classification:

435006000, 435007230, 435069100, 435320100, 435325000, 530350000, 435226000, 536023200

Abstract:

Rbx1, an evolutionarily conserved Cullin-interacting RING-H2 finger protein, has been discovered. Mammalian Rbx1 has been identified as a component of the CUL2-containing VHL complex. An Rbx1 homolog from has also been identified as a subunit and activator of the Cdc53-containing SCFubiquitin ligase required for ubiquitination of the cdk inhibitor Sic1 and for the G1/S cell cycle transition in yeast, providing a link between the multiprotein VHL tumor suppressor complex and cellular ubiquitination. The Rbx1 protein acts as a cellular marker useful (1) in detecting a possible predisposition to certain carcinomas, (2) as a molecular target for treating those carcinomas therapeutically, (3) as a target for inhibition by drugs that manipulate the growth of cells, and (4) as a research tool to better understand the various complex mechanisms of cell ubiquitination, binding of certain activator proteins, fibronectin deposition and other aspects of the cellular division process.

US Patent:

57926344, Aug 11, 1998

Filed:

Sep 7, 1995

Appl. No.:

8/524757

Inventors:

Ronald Charles Conaway - Oklahoma City OK
Joan Weliky Conaway - Oklahoma City OK
John N. Bradsher - New York NY

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C12N 900
C07K 1447

US Classification:

435183

Abstract:

A new RNA polymerase transcription factor has been discovered. The enzyme significantly increases the rate of transcription elongation by RNA polymerase II.

US Patent:

60840684, Jul 4, 2000

Filed:

Oct 4, 1996

Appl. No.:

8/725459

Inventors:

Ronald C. Conaway - Oklahoma City OK
Joan W. Conaway - Oklahoma City OK

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C07K 500

US Classification:

530350

Abstract:

The functional domains of Elongin A having transcriptional activation activity and Elongin BC binding activity and the functional domains of Elongin C having Elongin A activation activity and Elongin A and/or Elongin C binding activity have now been identified and isolated.