Ronald W Helms

US Patent:

20040073463, Apr 15, 2004

Filed:

Aug 13, 2003

Appl. No.:

10/640561

Inventors:

Russell Helms - Chapel Hill NC, US
Ronald Helms - Chapel Hill NC, US

International Classification:

G06F017/60

US Classification:

705/003000

Abstract:

An integrated clinical analysis database may include clinical data from observations of study subjects of a population of study subjects of a clinical study and metadata that defines a structuring of the clinical data that supports generation of a statistical analysis of the population of study subjects specified by study documentation of the clinical study. The metadata provides statistical variable definitions for the statistical analysis such that plural instances of the statistical analysis can be generated without determining new values for the statistical variables. Respective statistical analysis instructions may be accepted and, in response, the clinical study analysis database may be accessed and respective statistical computations may be performed using the statistical variables to generate respective instances of the statistical analysis. A user interface for presentation of the statistical analysis may be provided using, e.g., a web server. An integrated clinical study analysis database may include data and derivative data from study subjects, structured such that a statistic and/or a table value specified in documentation for the clinical study can be computed using published equations applied directly to existing values of variables in the database, and which includes at least two of: a dataset structured one record per subject; a dataset structure one record per visit per subject; a data structured one record per measurement occasion per visit per subject; and a dataset structured one record per event per subject.

US Patent:

20070112672, May 17, 2007

Filed:

Oct 11, 2006

Appl. No.:

11/548535

Inventors:

Ronald Helms - Chapel Hill NC, US

International Classification:

G06Q 40/00

US Classification:

705040000

Abstract:

A product risk acceptance contract (PRAC) system server communicates with a PRAC system provider client coupled thereto and responsively generates a record of an offer for a risk transfer for a product (e.g., a good, intangible asset and/or service). The PRAC system server further communicates with a PRAC system consumer client coupled thereto and responsively generates a record of an executed PRAC for the product based on the generated record of the offer for the risk transfer.

US Patent:

60597240, May 9, 2000

Filed:

Feb 14, 1997

Appl. No.:

8/800314

Inventors:

T. Colin Campell - Ithaca NY
Ronald W. Helms - Chapel Hill NC
Lisa Tomasko - Durham NC

Assignee:

BioSignal, Inc. - Chapel Hill NC

International Classification:

A61B 500

US Classification:

600300

Abstract:

A computer-based system is disclosed for predicting future health of individuals comprising: (a) a computer comprising a processor containing a database of longitudinally-acquired biomarker values from individual members of a test population, subpopulation D of aid members being identified as having acquired a specified biological condition within a specified time period or age interval and a subpopulation D being identified as not having acquired the specified biological condition within the specified time period or age interval; and (b) a computer program that includes steps for: (1) selecting from said biomarkers a subset of biomarkers for discriminating between members belonging to the subpopulations D and D, wherein the subset of biomarkers is selected based on distributions of the biomarker values of the individual members of the test population; and (2) using the distributions of the selected biomarkers to develop a statistical procedure that is capable of being used for: (i) classifying members of the test population as belonging within a subpopulation PD having a prescribed high probability of acquiring the specified biological condition within the specified time period or age interval or as belonging within a subpopulation PD having a prescribed low probability of acquiring the specified biological condition within the specified time period or age interval; or (ii) estimating quantitatively, for each member of the test population, the probability of acquiring the specified biological condition within the specified time period or age interval.