Ronald Scott Rasmussen

US Patent:

58637737, Jan 26, 1999

Filed:

Sep 30, 1997

Appl. No.:

8/940513

Inventors:

Geewananda P. Gunawardana - Libertyville IL
David Frost - Deerfield IL
Marianna Jackson - Waukegan IL
James P. Karwowski - Mundelein IL
Ronald R. Rasmussen - Burlington WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12P 102
C12P 1716
A61K 3135
C07D31500

US Classification:

435118

Abstract:

Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, wherein R is: ##STR2## --C(O)--R. sub. 1 wherein R. sub. 1 is alkyl, alkenyl, aryl, arylalkenyl, aryl-aryl-, arylalkoxy-aryl-, aryl-aryl-aryl-, arylkoxy-aryl-aryl-, or ##STR3## wherein R. sub. 2 is alkylamino, dialkylamino, (heterocyclic)alkyl, aryl, or arylalkyl; and X is O, NH, or NR. sub. 3 wherein R. sub. 3 is alkyl or aryl. Also disclosed are pharmaceutical compositions comprising a compound of the invention in combination with a pharmaceutically acceptable carrier; and a process for preparing the compounds of the invention.

US Patent:

53569334, Oct 18, 1994

Filed:

Jun 28, 1993

Appl. No.:

8/084335

Inventors:

Gregory M. Brill - Wildwood IL
James B. McAlpine - Libertyville IL
Ronald R. Rasmussen - Burlington WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A01N 3706
C07C 6122

US Classification:

514548

Abstract:

Novel compounds having the structural formula ##STR1## and pharmaceutically acceptable salts and prodrugs thereof, wherein one of R. sup. 1 and R. sup. 2 is hydrogen and the other is --CH. dbd. CHCOOH, X is >CH--, and Y is --0--; or, alternatively, the bond between X and Y is not present, X is --CH. sub. 2 --, and Y is --OH, as well as methods for their use, pharmaceutical compositions containing the same, and a process for their preparation via fermentation.

US Patent:

40082369, Feb 15, 1977

Filed:

Jul 31, 1975

Appl. No.:

5/601118

Inventors:

Thomas John Perun - Libertyville IL
Ronald Robert Rasmussen - Waukegan IL
Bruce Wayne Horrom - Waukegan IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

C07D23948

US Classification:

2602564N

Abstract:

This invention provides 2,4-diamino-5-benzylpyrimidines represented by the formula ##STR1## wherein R. sub. 1 is H or loweralkyl; R. sub. 2 is H, loweralkyl or R. sub. 3 CO-- wherein R. sub. 3 is H, alkyl, or cycloalkyl-loweralkyl; and X is a halogen; and the acid addition salts thereof. These pyrimidine compounds are useful as antibacterial agents, and as potentiators of the antibacterial activity of sulfonamides.

US Patent:

50304500, Jul 9, 1991

Filed:

Nov 28, 1989

Appl. No.:

7/442287

Inventors:

Premachandran Devidas - Grayslake IL
Ronald R. Rasmussen - Waukegan IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A01N 6500
A01N 6300

US Classification:

4241951

Abstract:

New trichothecene compositions are disclosed along with their use in methods of inhibiting nematode infection of plants.

US Patent:

40875288, May 2, 1978

Filed:

Oct 26, 1976

Appl. No.:

5/735301

Inventors:

Thomas John Perun - Libertyville IL
Ronald Robert Rasmussen - Waukegan IL
Bruce Wayne Horrom - Waukegan IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 31305
C07D23948

US Classification:

424251

Abstract:

This invention provides 2,4-diamino-5-benzylpyrimidines represented by the formula ##STR1## wherein R. sub. 1 is H or loweralkyl; R. sub. 2 is H, loweralkyl or R. sub. 3 CO-- wherein R. sub. 3 is H, alkyl, or cycloalkyl-lowerakyl; and X is a halogen; and the acid addition salts thereof. These pyrimidine compounds are useful as antibacterial agents, and as potentiators of the anti-bacterial activity of sulfonamides.

US Patent:

57670960, Jun 16, 1998

Filed:

Jul 12, 1996

Appl. No.:

8/678906

Inventors:

Jill E. Hochlowski - Green Oaks IL
Marianna Jackson - Waukegan IL
James B. McAlpine - Libertyville IL
Ronald R. Rasmussen - Burlington WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3171

US Classification:

514 28

Abstract:

Antimicrobial compounds having the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are independently selected from the group consisting of hydrogen and C. sub. 1 -to-C. sub. 4 alkanoyl; R. sup. 3 and R. sup. 4 are selected from the group consisting of (a) R. sup. 3 is hydrogen and R. sup. 4 is hydroxy, (b) R. sup. 3 is hydroxy and R. sup. 4 is hydrogen, (c) R. sup. 3 and R. sup. 4 taken together are. dbd. O; or selected from the group consisting of hydrogen and hydroxy; and R. sup. 5 and R. sup. 6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R. sup. 5 and R. sup. 6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.