Ronald E Seamans

US Patent:

56938454, Dec 2, 1997

Filed:

Mar 6, 1992

Appl. No.:

7/846509

Inventors:

Rex Allen Jennings - Holland MI
Don Richard Johnson - Pinckney MI
Ronald Everett Seamans - Holland MI
James Robert Zeller - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07C25500

US Classification:

558431

Abstract:

Novel cyanocycloalkylacetic acids and esters as well as salts thereof and in particular 1-cyanocyclohexaneacetic acid and ethyl 1-cyanocyclohexaneacetate are described which are useful as intermediates in a process for the preparation of cyclic amino acids.

US Patent:

53628837, Nov 8, 1994

Filed:

Mar 8, 1994

Appl. No.:

8/208771

Inventors:

Rex A. Jennings - Holland MI
Don R. Johnson - Pinckney MI
Ronald E. Seamans - Holland MI
James R. Zeller - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D20954

US Classification:

548408

Abstract:

An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.

US Patent:

53191358, Jun 7, 1994

Filed:

Jun 4, 1993

Appl. No.:

8/072212

Inventors:

Rex A. Jennings - Holland MI
Don R. Johnson - Pinckney MI
Ronald E. Seamans - Holland MI
James R. Zeller - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07C22722
C07D20996

US Classification:

562507

Abstract:

An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.

US Patent:

53860314, Jan 31, 1995

Filed:

Dec 15, 1993

Appl. No.:

8/167751

Inventors:

Randall L. De Jong - Zealand MI
Ronald E. Seamans - Holland MI
James R. Zeller - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D48704
C07B 3100

US Classification:

544280

Abstract:

An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-one is converted to a diazonium salt which is subsequently catalytically hydrogenated to the desired compound, as well as valuable intermediates used in the process.

US Patent:

44903863, Dec 25, 1984

Filed:

Sep 23, 1982

Appl. No.:

6/422499

Inventors:

Ronald E. Seamans - Holland MI
Walter E. Behnke - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31405
C07D20918

US Classification:

424274

Abstract:

Phosphate salts of the substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid are produced by treating a suitably substituted octahydro-1H-indole with phosphoric acid. The phosphate salts of the compounds and pharmaceutical compositions thereof are useful as antihypertensive agents.

US Patent:

51324512, Jul 21, 1992

Filed:

Aug 10, 1990

Appl. No.:

7/564623

Inventors:

Rex A. Jennings - Holland MI
Don R. Johnson - Pinckney MI
Ronald E. Seamans - Holland MI
James R. Zeller - Holland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07C 6108

US Classification:

562507

Abstract:

An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.