Rong Li

US Patent:

20230130372, Apr 27, 2023

Filed:

Dec 17, 2020

Appl. No.:

17/757510

Inventors:

- Austin TX, US
- Washington DC, US
Hui DENG - Houston TX, US
Xiujie SUN - Washington DC, US
Rong LI - Washington DC, US

International Classification:

C07K 16/28
C12N 15/63
A61P 35/00

Abstract:

The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer. Thus, in one aspect, the present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to DDR1. In certain embodiments, the antibody or antigen-binding fragment, when bound to DDR1, modulates the activity of DDR1, i.e., suppresses DDR1.