Dan R. Littman - New York NY, US Hongkui Deng - Worcester MA, US Wilfried Ellmeier - New York NY, US Nathaniel R. Landau - New York NY, US Rong Liu - New York NY, US
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the β-chemokines RANTES, MIP-1α, and MIP-1β.
David Cohn - Dobbs Ferry NY, US Pankaj Dhoolia - New Delhi, IN Hemesh Kumar - New Delhi, IN Santhosh Kumaran - Peekskill NY, US Rong Liu - Sterling VA, US Florian Pinel - New York NY, US
Assignee:
International Business Machines Corporation - Armonk NY
International Classification:
G06F 9/45
US Classification:
703 22, 718100
Abstract:
Techniques for modeling a composite application are provided. The techniques include identifying one or more entities that are processed in a user enterprise, identifying one or more actions to be performed during a lifecycle of the one or more entities, and modeling a composite application based on the one or more actions to be performed during a lifecycle of the one or more entities.
Methods Of Identifying G-Coupled Receptors Associated With Macrophage-Trophic Hiv, And Diagnostic And Therapeutic Uses Thereof
Dan R. Littman - New York NY Hongkui Deng - Worcester MA Wilfried Ellmeier - New York NY Nathaniel R. Landau - New York NY Rong Liu - New York NY
Assignee:
The Aaron Diamond Aids Research Center - New York NY New York University - New York NY
International Classification:
C12Q 170 G01N 33567 C12N 510
US Classification:
435 5
Abstract:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the. beta. -chemokines RANTES, MIP-1. alpha. , and MIP-1. beta.
Nathaniel R. Landau - New York NY Richard A. Koup - Southlake TX Rong Liu - New York NY William Paxton - Amsterdam, NL
Assignee:
The Aaron Diamond Aids Research Center - New York NY
International Classification:
C12Q 168 C12Q 170
US Classification:
435 6
Abstract:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the. beta. -chemokines RANTES, MIP-1. alpha. , and MIP-1. beta. It has also been found that individuals who are homozygous for a mutation of the CKR-5 receptor are resistent to HIV infection; in vitro infection requires a 1000-fold higher dose of HIV than normal cells. The mutation results in complete suppression of CKR-5 expression.
G-Coupled Receptors Associated With Macrophage-Trophic Hiv, And Diagnostic And Therapeutic Uses Thereof
Dan R. Littman - New York NY Hongkui Deng - New York NY Wilfried Ellmeier - New York NY Nathaniel R. Landau - New York NY Rong Liu - New York NY
Assignee:
New York University - New York NY The Aaron Diamond Aids Research Center - New York NY
International Classification:
C12N 506 C12N 510 C12N 508
US Classification:
435325
Abstract:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the. beta. -chemokines RANTES, MIP-1. alpha. , and MIP-1. beta.
Hierarchical Video Concept Tagging And Indexing System For Learning Content Orchestration
- ARMONK NY, US Ashish Jagmohan - Irvington NY, US Ravindranath Kokku - Yorktown Heights NY, US Rong Liu - Sterling VA, US Satyanarayana V. Nitta - Westchester NY, US
A computer system, method, and computer-readable product for automatically generating a hierarchy of concepts described in a video using semantic concept matching that assists persons in searching for specific types of content within videos. A video segment is obtained, with the segment having a distinct running time with discrete information related to one or more topics within its content. The discrete information of the video segment is then parsed out and related to a predetermined relevant topic, and then one or more attributes for weighting each discrete information relevant topic within the video segment are determined. A hierarchy of concepts of the video segments is then created, based upon, at least, the weighting of the information topic within the running time of the video segment based upon the presence of the one or more attributes. Other information related to the video segment can also be used to modify the hierarchy.
Recommending Personalized Jobs From Automated Review Of Writing Samples And Resumes
- ARMONK NY, US Ashish Jagmohan - Irvington NY, US Ravindranath Kokku - Yorktown Heights NY, US Rong Liu - Sterling VA, US Satyanarayana V. Nitta - Cross River NY, US
International Classification:
G06Q 10/06 G06Q 10/10 G06F 17/30
Abstract:
A computer system, method, and computer-readable product for providing data for career advice, such as job or education recommendations, from automated review and analysis of career-related data for an individual, which is at least initially obtained from documents, such as resumes and writing samples. For a designated individual, career-related data is obtained from the documents and an initial personality estimate is created for the designated individual based upon, at least, the obtained career-related data. One or more latent factor models for known career-personality matches are then gathered from a database and a questionnaire is provided to the individual to gather further information and augment the personality estimate. The created personality estimate is integrated with the latent factor model(s) to create career advice data.
Hierarchical Video Concept Tagging And Indexing System For Learning Content Orchestration
- Armonk NY, US Ashish Jagmohan - Irvington NY, US Ravindranath Kokku - Yorktown Heights NY, US Rong Liu - Sterling VA, US Satyanarayana V. Nitta - Cross River NY, US
A computer system, method, and computer-readable product for automatically generating a hierarchy of concepts described in a video using semantic concept matching that assists persons in searching for specific types of content within videos. A video segment is obtained, with the segment having a distinct running time with discrete information related to one or more topics within its content. The discrete information of the video segment is then parsed out and related to a predetermined relevant topic, and then one or more attributes for weighting each discrete information relevant topic within the video segment are determined. A hierarchy of concepts of the video segments is then created, based upon, at least, the weighting of the information topic within the running time of the video segment based upon the presence of the one or more attributes. Other information related to the video segment can also be used to modify the hierarchy.