Rong Jian Lu

US Patent:

20060025594, Feb 2, 2006

Filed:

Mar 11, 2003

Appl. No.:

10/507180

Inventors:

Marie-Pierre De Bethune - Everberg, BE
Sandra De Meyer - Beerse, BE
Kurt Hertogs - Antwerpen, BE
Rong Lu - Chapel Hill NC, US
Lieve Michiels - Mol, BE
Abdellah Tahri - Anderlecht, BE
Dong Xie - Germantown MD, US
Michael Eissenstat - Frederick MD, US

Assignee:

TIBOTEC Pharmaceuticals Ltd. - Blanchardstown, Dublin

International Classification:

C07D 213/24
C07F 7/02

US Classification:

546014000, 546334000, 562450000

Abstract:

The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.

US Patent:

20070259879, Nov 8, 2007

Filed:

Mar 6, 2007

Appl. No.:

11/714539

Inventors:

Rong Lu - Chapel Hill NC, US
John Tucker - San Diego CA, US
Jason Pickens - San Diego CA, US
Tatiana Zinevitch - Moscow, RU
Sergey Sviridov - Moscow, RU
Vitaly Konoplev - Toulskaya, RU
Enugurthi Brahmachary - San Diego CA, US

International Classification:

A61K 31/505
A61K 31/497
A61P 37/00
C07D 241/36
C07D 401/02
C07D 403/02
C07D 405/02
C07D 413/02
C07D 495/02

US Classification:

514252130, 514253010, 514253060, 514254020, 514254030, 514254050, 514254080, 514255020, 514274000, 544278000, 544295000, 544360000, 544363000, 544366000, 544367000, 544369000, 544370000, 544371000, 544373000, 544374000, 544383000

Abstract:

This invention relates to piperazine and piperidine biaryl compounds of Formula (I): or a pharmaceutically acceptable prodrug, salt, polymorph, solvate, enantiomer, diastereomer, racemate, mixture of stereoisomers thereof, or derivative thereof; and to processes for preparing the compounds or pharmaceutical compositions containing the same. The compounds and pharmaceutical compositions of the present invention are provided for use in the treatment of HIV infection and/or AIDS.