Russell C Martin

US Patent:

20220339321, Oct 27, 2022

Filed:

Jun 23, 2022

Appl. No.:

17/847832

Inventors:

- Baltimore MD, US
Sashank Reddy - Baltimore MD, US
Gerald Brandacher - Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Justin Sacks - Baltimore MD, US
Xiaowei Li - Towson MD, US
Kevin Feng - Baltimore MD, US
Russell Martin - Baltimore MD, US
Georgia C. Yalanis - Baltimore MD, US
Ji Suk Choi - Baltimore MD, US

International Classification:

A61L 27/52
A61L 27/16
A61L 27/24
A61L 27/36
A61L 27/56
A61L 27/58
A61L 27/18

Abstract:

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

US Patent:

20210402061, Dec 30, 2021

Filed:

May 9, 2019

Appl. No.:

17/054156

Inventors:

- Baltimore MD, US
Russell Martin - Baltimore MD, US
Xiaowei Li - Towson MD, US
Calvin Chang - Baltimore MD, US
Kevin Colbert - Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US

International Classification:

A61L 27/38
A61L 27/18
A61L 27/20
A61L 27/48
A61L 27/52
A61L 27/54
A61L 27/56
A61L 27/58

Abstract:

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

US Patent:

20200030496, Jan 30, 2020

Filed:

Jul 18, 2019

Appl. No.:

16/515946

Inventors:

- Baltimore MD, US
Russell Martin - Baltimore MD, US
Xiaowei Li - Towson MD, US
Calvin Chang - Baltimore MD, US
Kevin Colbert - Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US

International Classification:

A61L 27/58
A61L 27/54
A61L 27/20
A61L 27/18
A61L 27/44
A61L 27/52
A61L 27/38
A61M 5/19

Abstract:

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

US Patent:

20190388588, Dec 26, 2019

Filed:

Aug 6, 2019

Appl. No.:

16/533375

Inventors:

- Baltimore MD, US
Sashank Reddy - Baltimore MD, US
Gerald Brandacher - Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Justin Sacks - Baltimore MD, US
Xiaowei Li - Towson MD, US
Kevin Feng - Baltimore MD, US
Russell Martin - Baltimore MD, US
Georgia C. Yalanis - Baltimore MD, US
Ji Suk Choi - Baltimore MD, US

International Classification:

A61L 27/52
A61L 27/16
A61L 27/24
A61L 27/36
A61L 27/56
A61L 27/58

Abstract:

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

US Patent:

20180050130, Feb 22, 2018

Filed:

Feb 14, 2017

Appl. No.:

15/432606

Inventors:

- Baltimore MD, US
Sashank Reddy - Baltimore MD, US
Gerald Brandacher - Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Justin Sacks - Baltimore MD, US
Xiaowei Li - Henrico VA, US
Kevin Feng - Baltimore MD, US
Russell Martin - Baltimore MD, US
George C. Yalanis - Baltimore MD, US
Ji Suk Choi - Baltimore MD, US

International Classification:

A61L 27/52
A61L 27/36
A61L 27/24
A61L 27/56

Abstract:

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

US Patent:

20170095591, Apr 6, 2017

Filed:

Apr 9, 2015

Appl. No.:

15/128257

Inventors:

- Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Kellin Krick - Baltimore MD, US
Russell Martin - Baltimore MD, US
Gerald Brandacher - Baltimore MD, US

International Classification:

A61L 27/18
D01F 8/14
D01D 5/00
A61L 27/56
A61L 27/26

Abstract:

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 μm thick with pores smaller than 25 μm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

US Patent:

20150125495, May 7, 2015

Filed:

May 17, 2013

Appl. No.:

14/400856

Inventors:

- Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Corinne Keet - Baltimore MD, US
Russell Martin - Los Gatos CA, US

Assignee:

John Hopkins University - Baltimore MD

International Classification:

A61K 47/38
A61K 9/00
B29C 39/02
A61K 39/35
A61K 47/26
A61K 45/06
A61K 9/70
A61K 47/10

US Classification:

424400, 4242751, 424 856, 264145

Abstract:

The present invention provides a thin mucoadhesive sublingual film composition which provides improved allergen delivery and efficacy at a smaller dose while prolonging the contact time between the allergen and oral antigen presenting cells (APCs), and therefore minimizing the risk of systemic side effects. The thin film compositions of the present invention are also easier to standardize, and removes any need for measuring allergen doses at the physician's office, and which allows for a simplified dosing schedule. Methods of making the thin film compositions and methods for their use are also disclosed.