Russell D Thomas

US Patent:

20130029334, Jan 31, 2013

Filed:

Mar 2, 2011

Appl. No.:

13/580492

Inventors:

Russell S. Thomas - Durham NC, US
Barbara A. Wetmore - Raleigh NC, US

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The present invention provides a method for assessing the likelihood or for detecting the presence of liver perturbation in an individual. The method is particularly useful for detecting drug-induced liver injury (DILI) or other forms of hepatotoxicity or hepatic perturbation. The method comprises measuring the level of at least one RNA biomarker comprising mRNA and comparing the measured level to an appropriate reference value for the sample type and RNA biomarker type, and wherein a significant difference between the measured level and the reference value is indicative of liver perturbation.

US Patent:

20210361783, Nov 25, 2021

Filed:

Jan 4, 2021

Appl. No.:

17/140920

Inventors:

- Durham NC, US
Russell D. Thomas - Wake Forest NC, US
Joshua O. Akhigbe - Durham NC, US

Assignee:

NIRvana Sciences Inc. - Durham NC

International Classification:

A61K 49/22
G01N 29/24
A61B 5/00

Abstract:

Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.