Ruth Anne Jones

US Patent:

45282676, Jul 9, 1985

Filed:

Mar 17, 1983

Appl. No.:

6/476440

Inventors:

Emanuel Calenoff - Burlingame CA
Yuh-Geng Tsay - San Jose CA
Ruth M. Jones - Los Altos CA

Assignee:

Axionics, Inc. - CA

International Classification:

G01N 3354

US Classification:

435 7

Abstract:

An inhibition assay for measuring the potency of allergen extracts by incubating a mixture of allergen extract and reference allergen specific IgE in a buffered solution with an insoluble support to which reference allergen is adhered. The conjugated IgE adhering to the insoluble support is reacted with an enzyme labeled anti-IgE antibody and the enzyme label is contacted with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme. The level of fluoresence in the solution is measured. The percentage of inhibition of the allergen specific IgE is determined from fluorescence levels measured for various extract concentrations.

US Patent:

43394418, Jul 13, 1982

Filed:

Oct 30, 1981

Appl. No.:

6/316926

Inventors:

Sumner M. Kalman - Palo Alto CA
Ruth M. Jones - Redwood City CA

International Classification:

A61K 3700
A61K 3514

US Classification:

424177

Abstract:

A proteinaceous cardioactive factor that exhibits positive inotropic activity and positive chronotropic activity has been partially extracted from mammalian plasma by precipitation with polyethylene glycol followed by cation exchange chromatography. The factor may be fractionated into two active fractions, one having an apparent molecular weight of about 130,000 daltons and the other having an apparent molecular weight of about 30,000 daltons, by gel filtration chromatography.

US Patent:

50843796, Jan 28, 1992

Filed:

May 25, 1990

Appl. No.:

7/529784

Inventors:

Emanuel Calenoff - Burlingame CA
Ruth M. Jones - Redwood City CA
Yuh-Geng Tsay - San Jose CA
Myron A. Beigler - Los Altos Hills CA

Assignee:

BioWhittaker, Inc. - Walkersville MD

International Classification:

C12Q 137
G01N 3353

US Classification:

435 71

Abstract:

A method for identifying and quantifying chymopapain-specific IgE antibody levels in patient serum comprising binding chymopapain-specific IgE, if any, in the serum with chymopapain adhering to an insoluble support, conjugating the serum IgE with a labeled anti-IgE antibody, and measuring the level of labeled compound bound to the insoluble support or in the solution removed therefrom. Special reagents and their manufacture are also disclosed.

US Patent:

48449660, Jul 4, 1989

Filed:

Jan 15, 1988

Appl. No.:

7/144738

Inventors:

Emanuel Calenoff - Burlingame CA
Ruth M. Jones - Los Altos CA
John R. Scott - Mountain View CA

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

G01N 3353

US Classification:

435 7

Abstract:

A method for identifying and quantifying total IgE levels in patient serum by conjugating the IgE in the serum with anti-IgE antibody adhering to an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme label with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluoresence in the solution. Special reagents and their manufacture are also disclosed.

US Patent:

44990650, Feb 12, 1985

Filed:

Apr 29, 1983

Appl. No.:

6/489898

Inventors:

Emanuel Calenoff - Burlingame CA
Ruth M. Jones - Redwood City CA
Yuh-Geng Tsay - San Jose CA
Myron A. Beigler - Los Altos Hills CA

Assignee:

Axonica, Inc. - Mt. View CA

International Classification:

A61K 3935
A61K 4900
C12N 999
C12N 950

US Classification:

424 9

Abstract:

A chymopapain derivative having the enzymatic activity reduced by at least 95% while retaining the original allergenic activity of at least 90% is suitable for skin testing to detect allergic hypersensitivity to chymopapain and for treating patients exhibiting allergic hypersensitivity to chymopapain. The enzymatic activity can be blocked by reacting thiol groups of the enzyme with and iodoacetic acid, bromoacetic acid, or a salt, ester or amide derivative thereof, under conditions which block the undesirable enzymatic activity while retaining the desired allergenic activity.

US Patent:

48493376, Jul 18, 1989

Filed:

Jan 14, 1988

Appl. No.:

7/144730

Inventors:

Emanuel Calenoff - Burlingame CA
Ruth M. Jones - Los Altos CA
Yuh-Geng Tsay - San Jose CA
John R. Scott - Mountain View CA

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

G10N 3353
G10N 33577

US Classification:

435 7

Abstract:

A method for identifying and quantifying allergen specific IgE levels in patent serum by conjugating the IgE in the serum with allergens adhering to an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme label with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluorescence in the solution. Special reagents and their manufacture are also disclosed.

Address:

310 E Dormard Ave, Midland, TX 79705

VIN:

1FMEU31K37UA28949

Make:

FORD

Model:

EXPLORER SPORT TRAC

Year:

2007