Ruth B Simon

US Patent:

20090233986, Sep 17, 2009

Filed:

Jul 22, 2005

Appl. No.:

11/658460

Inventors:

Ruth Simon - New York NY, US
Thomas Lufkin - Singapore, SG

Assignee:

MOUNT SINAI SCHOOL OF MEDICINE - New York NY

International Classification:

A61K 31/7052
C07H 21/00
C12N 15/63
C12N 5/00
C12N 1/21
C12N 1/19
C12N 5/06
C07K 14/00
C07K 7/06
C07K 7/08
C07K 16/00
A61P 3/00

US Classification:

514 44 R, 536 235, 4353201, 435325, 4352523, 4352542, 435348, 530350, 530328, 530327, 530326, 530325, 530324, 5303879, 435375

Abstract:

The present invention is generally directed to factors involved in energy metabolism. More specifically, a new gene is identified and shown to be a homeobox Sax2 gene that is involved with an obesity phenotype. Deletion of the causes growth retardation starting at birth and high postnatal lethality. Further, abrogation of the gene leads to a lack of fat accumulation in white adipose tissue and brown adipose tissue, as well as low blood glucose levels. Methods and compositions for making and using the product of the gene as well as for the manufacture of medicament for the treatment of obesity and obesity-related disorders are described.