Ryan J Mccarthy

US Patent:

20230061456, Mar 2, 2023

Filed:

Jan 22, 2021

Appl. No.:

17/794673

Inventors:

- Boston MA, US
Noah DRUCKENBROD - Dedham MA, US
Tyler GIBSON - Boston MA, US
Ryan MCCARTHY - Ashland MA, US
Jonathan B. SELLON - Boston MA, US
Kathy SO - Boston MA, US

International Classification:

C12N 15/113
C12N 15/86
A61K 38/17
A61K 31/713

Abstract:

The disclosure provides Sox2 inhibitors that can be used to generate Type I vestibular hair cells in the vestibular system. The Sox2 inhibitors may be administered to a subject alone or in combination with a regeneration agent to convert Type II vestibular hair cells or regenerated vestibular hair cells to Type I vestibular hair cells.

US Patent:

20180100840, Apr 12, 2018

Filed:

Dec 11, 2017

Appl. No.:

15/838081

Inventors:

- Sunnyvale CA, US
Paul H. GAMACHE - Hudson NH, US
Ryan S. McCARTHY - Lowell MA, US

International Classification:

G01N 30/84
G01N 30/64

Abstract:

A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector.

US Patent:

20140352411, Dec 4, 2014

Filed:

May 28, 2014

Appl. No.:

14/288693

Inventors:

- Sunnyvale CA, US
Paul H. GAMACHE - Hudson NH, US
Ryan S. McCARTHY - Lowell MA, US

Assignee:

DIONEX CORPORATION - Sunnyvale CA

International Classification:

G01N 30/84
B05B 7/00

US Classification:

73 6156, 239398

Abstract:

A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector.