Pravin Iyer - Mountain View CA, US Matthew C. Lucas - Sunnyvale CA, US Ryan Craig Schoenfeld - San Jose CA, US Marzia Villa - Sunnyvale CA, US Robert James Weikert - Boulder Creek CA, US
The present invention provides compounds of the formula:wherein p, Ar, R, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
Christine E. Brotherton-Pleiss - Sunnyvale CA, US Michael Patrick Dillon - San Francisco CA, US Shelley K. Gleason - Redwood City CA, US Clara Jeou Jen Lin - Palo Alto CA, US Ryan Craig Schoenfeld - San Jose CA, US Marzia Villa - Sunnyvale CA, US Yansheng Zhai - East Palo Alto CA, US
Pravin Iyer - Mountain View CA, US Matthew C. Lucas - Sunnyvale CA, US Ryan Craig Schoenfeld - San Jose CA, US Marzia Villa - Sunnyvale CA, US Robert James Weikert - Boulder Creek CA, US
David Scott Carter - Sunnyvale CA, US Matthew C. Lucas - Sunnyvale CA, US Ryan Craig Schoenfeld - San Jose CA, US Robert James Weikert - Boulder Creek CA, US
Javier de Vicente Fidalgo - Glen Ridge NJ, US Jim Li - San Francisco CA, US Ryan Craig Schoenfeld - San Jose CA, US Francisco Xavier Talamas - Mountain View CA, US Joshua Paul Gergely Taygerly - San Francisco CA, US
Jim Li - San Francisco CA, US Javier de Vincente Fidalgo - Glen Ridge NJ, US Ryan Craig Schoenfeld - Basking Ridge NJ, US Francisco Xavier Talamas - Livingston NJ, US
Assignee:
Roche Palo Alto LLC - South San Francisco CA
International Classification:
A01N 43/40 A61K 31/44 C07D 421/00
US Classification:
514332, 514277, 546255, 5462681
Abstract:
Compounds having the formula I wherein R, R, R, R, and Rare as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
Director, Medicinal Chemistry at CHDI Foundation, Inc.
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
CHDI Foundation, Inc. - Princeton, NJ since Nov 2012
Director, Medicinal Chemistry
Hoffmann-La Roche Jan 2012 - Nov 2012
Principal Scientist and Head of Innovation and Collaborative Research
Hoffmann-La Roche Aug 2010 - Dec 2011
Senior Scientist and Section Head, Exploratory Inflammation Chemistry
Roche Palo Alto Oct 2000 - Aug 2010
Research Scientist, Medicinal Chemistry
Centaur Pharmaceuticals 1994 - 1996
Research Associate
Education:
Cornell University 1996 - 2000
Ph.D., Chemistry
California Polytechnic State University-San Luis Obispo 1989 - 1994
B.S., Chemistry