Alexander Gaiger - Seattle WA, US Molly Smithgall - Seattle WA, US Darrick Carter - Seattle WA, US Martin Cheever - Mercer Island WA, US Patricia McNeill - Federal Way WA, US R. Sutherland - Bothell WA, US Sally Mossman - Seattle WA, US Lawrence Evans - Seattle WA, US Ryan Swanson - Seattle WA, US
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
Compositions and methods comprising a recombinant virus and an immunostimulant are provided for enhancing the immune response to a polypeptide expressed from the recombinant virus. Preferably this is done without also enhancing the neutralizing antibody response to the recombinant virus. Illustrative compositions comprise an adenovirus and an adjuvant such as, for example, monophosphoryl lipid A, an alkyl glucosaminide phosphate, a saponin, or a combination thereof. The disclosed compositions and methods are useful, for example, in the treatment of diseases such as cancer or infectious disease.
Compositions And Methods For Wt1 Specific Immunotherapy
Alexander Gaiger - Seattle WA, US Molly Smithgall - Seattle WA, US Darrick Carter - Seattle WA, US Martin Cheever - Mercer Island WA, US Patricia McNeill - Federal Way WA, US R. Sutherland - Bothell WA, US Sally Mossman - Seattle WA, US Lawrence Evans - Seattle WA, US Ryan Swanson - Seattle WA, US
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K048/00
US Classification:
424/093200, 514/012000, 514/044000
Abstract:
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
Btnl9 Proteins, Nucleic Acids, And Antibodies And Uses Thereof
The invention provides novel BTNL9 proteins, including multimers, fragments, and variants of a human BTNL9 protein. In addition, antibodies that can bind to BTNL9 proteins and nucleic acids encoding BTNL9 proteins are provided. Uses for BTNL9 proteins, and agonists or antagonists thereof, are described.
Compositions And Methods For The Diagnosis And Threatment Of Herpes Simplex Virus Infection
Nancy Hosken - Seattle WA, US Patrick McGowan - Seattle WA, US Paul Sleath - Seattle WA, US Sally Mossman - Seattle WA, US Lawrence Evans - Seattle WA, US Ryan Swanson - Seattle WA, US Patricia McNeill - Federal Way WA, US
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K039/12 C12N009/50 C07H021/04 C12P021/06
US Classification:
424/186100, 435/219000, 536/023720, 435/069100
Abstract:
Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
Multi-Domain Immunomodulatory Proteins And Methods Of Use Thereof
Provided herein are multi-domain immunomodulatory proteins, nucleic acids encoding such immunomodulatory proteins, cells engineered to express the immunomodulatory proteins and infectious agents containing nucleic acid encoding the immunomodulatory proteins. The immunomodulatory proteins bind both an inhibitory receptor and a receptor involved in activation signaling cascades in an immune cell, such as a T cell. The immunomodulatory proteins, engineered cells and infectious agents provide therapeutic utility for a variety of immunological diseases or conditions. Compositions and methods for making and using such proteins are provided.
Ctla-4 Variant Immunomodulatory Proteins And Uses Thereof
Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
Variant Icos Ligand Immunomodulatory Proteins And Related Compositions And Methods
Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
Aug 2013 to 2000 Financial Assistance AdvisorHomeGoods Lemont, IL Aug 2010 to Mar 2013 Sales AssociatePacific Sunwear Bolingbrook, IL Oct 2007 to Mar 2009 Brand RepresentativeLemont High School Boy's Tennis Club
2007 to 2009 MemberLemont High School Boy's Tennis Club
2005 to 2009 Member
Education:
DeVry University Tinley Park, IL Jan 2010 to Feb 2012 Bachelor's in Business AdministrationUniversity of Iowa Iowa City, IA Aug 2009 to Dec 2009
amateur -- in other words, someone who is not trying to make his living on tour. A few weeks ago at the Lecom Health Challenge in Findley Lake, New York, the unrestricted exemptions went to Dwayne Randall, the director of golf at the host resort, and Ryan Swanson, the men's golf coach at nearby St.