Ryan D Woodyer from 129 Sedgefield Overlook, Dallas, GA 30157, age 45

Phosphite Dehydrogenase Mutants For Nicotinamide Cofactor Regeneration
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US Patent:

7402419, Jul 22, 2008
Filed:

Jun 10, 2004
Appl. No.:

10/865146
Inventors:

Huimin Zhao - Champaign IL, US
William W. Metcalf - Savoy IL, US
Wilfred A. van der Donk - Champaign IL, US
Tyler Johnannes - Urbana IL, US
Ryan Woodyer - Champaign IL, US
Assignee:

Biotechnology Research and Development Corporation - Peoria IL
Board of Trustees of the University of Illinois - Urbana IL
International Classification:

C12N 9/04
C12N 15/00
C12N 1/20
C12Q 1/00
C12Q 1/68
C07H 21/04
C12P 21/04
US Classification:

435190, 435440, 435 691, 435 711, 4353201, 4352523, 435 4, 435 6, 536 232
Abstract:

Phosphite dehydrogenase mutant enzymes were generated that provide relaxed cofactor specificity and increased thermostability over the wild type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.

Highly Active Xylose Reductase From
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US Patent:

7592163, Sep 22, 2009
Filed:

May 19, 2008
Appl. No.:

12/123279
Inventors:

Huimin Zhao - Champaign IL, US
Ryan Woodyer - Champaign IL, US
Michael Simurdiak - Urbana IL, US
Wilfred A. van der Donk - Champaign IL, US
Assignee:

The Board of Trustees of the University of Illinois - Urbana IL
Biotechnology Research and Development Corporation - Peoria IL
International Classification:

C12P 19/02
C12N 9/02
US Classification:

435105, 435189
Abstract:

A new xylose reductase encoding gene from was heterologously expressed in as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.

Highly Active Xylose Reductase From Neurospora Crassa
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US Patent:

20060035353, Feb 16, 2006
Filed:

Jun 14, 2005
Appl. No.:

11/151762
Inventors:

Huimin Zhao - Champaign IL, US
Ryan Woodyer - Champaign IL, US
Michael Simurdiak - Urbana IL, US
Wilfred van der Donk - Champaign IL, US
International Classification:

C12P 7/18
C12N 9/02
C12N 1/20
US Classification:

435158000, 435189000, 435252300
Abstract:

A new xylose reductase encoding gene from was heterologously expressed in as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.

Highly Active Xylose Reductase From Neurospora Crassa
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US Patent:

20090325254, Dec 31, 2009
Filed:

Sep 1, 2009
Appl. No.:

12/551721
Inventors:

Huimin Zhao - Champaign IL, US
Ryan Woodyer - Champaign IL, US
Michael Simurdiak - Urbana IL, US
Wilfred A. van der Donk - Champaign IL, US
Assignee:

BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION - PEORIA IL
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - URBANA IL
International Classification:

C12P 7/10
C12N 9/02
US Classification:

435165, 435189
Abstract:

A new xylose reductase encoding gene from was heterologously expressed in as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.

Production Of L-Ribose And Other Rare Sugars
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US Patent:

20120021468, Jan 26, 2012
Filed:

Aug 20, 2009
Appl. No.:

13/059746
Inventors:

Ryan Woodyer - Normal IL, US
Francis Michael Racine - Peoria IL, US
Assignee:

ZUCHEM, INC. - Chicago IL
International Classification:

C12P 19/02
C07H 21/00
C12P 7/24
C12N 9/04
US Classification:

435105, 435190, 536 232, 435147
Abstract:

The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase or a polyol-1-dehydrogenase.

Production Of Xylitol From A Mixture Of Hemicellulosic Sugars
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US Patent:

20130065288, Mar 14, 2013
Filed:

Jan 14, 2011
Appl. No.:

13/521366
Inventors:

Huimin Zhao - Champaign IL, US
Nikhil Unni Nair - Urbana IL, US
Michael Racine - Peoria IL, US
Ryan Woodyer - Normal IL, US
Assignee:

ZUCHEM INC. - Chicago IL
International Classification:

C12P 7/18
C12N 1/20
US Classification:

435158, 4352528
Abstract:

Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct co-product of a biorefinery or ethanol facility, or as a stand-alone product produced from an agricultural or forestry biomass feedstock including using, e.g. ethanol waste streams.

Production Of Xylitol From A Mixture Of Hemicellulosic Sugars
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US Patent:

20130217070, Aug 22, 2013
Filed:

Jul 20, 2011
Appl. No.:

13/877803
Inventors:

Huimin Zhao - Champaign IL, US
Nikhil Unni Nair - Urbana IL, US
Michael Racine - Peoria IL, US
Ryan Woodyer - Normal IL, US
Assignee:

ZUCHEM INC. - Chicago IL
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL
International Classification:

C12P 19/00
US Classification:

435 72, 43525233
Abstract:

Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct co-product of a biorefinery or ethanol facility, or as a stand-alone product produced from an agricultural or forestry biomass feedstock including using, e.g. ethanol waste streams.

Activated Sugars
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US Patent:

20140024082, Jan 23, 2014
Filed:

Aug 22, 2011
Appl. No.:

13/817888
Inventors:

Ryan Woodyer - Carpentersville IL, US
Paul Taylor - Arlington Heights IL, US
David Demirjian - Hinsdale IL, US
International Classification:

C12P 19/18
US Classification:

435 97, 435194, 536 232, 4353201
Abstract:

Kinase and nucleotidyltransferase enzymes for the production of activated sugars have been developed. These enzymes have improved stability for industrial application and relaxed specificity towards a variety of sugars. These enzymes are useful in, for example, the production of diverse NDP-sugars for glycosylation of aglycones of interest, production of oligosaccharides, production of other important glycosylated sugars, and in drug discovery applications.