Sally R Postlethwaite from 2717 Sussex Way, Redwood City, CA 94061, age 48, Phone: (650)4443340

Resumes

Principal Scientist

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Location:

Redwood City, CA

Industry:

Biotechnology

Work:

Applied Molecular Transport
Principal Scientist
Sutro Biopharma, Inc. Sep 2014 - Jan 2017
Senior Scientist, Fermentation and Upstream Process Development
Codexis, Inc. Jan 2012 - Sep 2014
Senior Scientist, Fermentation R and D and Process Development
Codexis, Inc. Oct 2004 - Jan 2012
Staff Scientist, Biocatalyst Evolution and Development

Education:

Ucl 1999 - 2003
University of Cambridge 1995 - 1999

Skills:

Fermentation
Technology Transfer
Biofuels
High Throughput Screening
Biotechnology
Protein Engineering
Fermentation Process Development
Biochemical Engineering
Biocatalysis
Enzymes
Protein Expression
Enzyme Assays
Technical Project Leadership
Filtration
Technical Project Management
Downstream Processing

Us Patents

Beta-Glucosidase Variant Enzymes And Related Polynucleotides
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US Patent:

20100317059, Dec 16, 2010
Filed:

Jun 16, 2010
Appl. No.:

12/816989
Inventors:

Sally Rhiannon Postlethwaite - Redwood City CA, US
Louis Clark - San Francisco CA, US
Assignee:

CODEXIS, INC. - Redwood City CA
International Classification:

C12P 19/00
C12N 9/42
C07H 21/04
C12N 15/63
C12N 1/21
C12P 7/06
US Classification:

435 72, 435209, 536 232, 4353201, 43525231, 435161, 43525233
Abstract:

The invention provides variants of the CelA β-glucosidase that have improve β-glucosidase activity, particularly improved thermoactivity, compared to the wild type enzyme. The invention further provides related polynucleotides, vectors, host cell, and methods for making and using the variants.

Beta-Glucosidase Variants
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US Patent:

20120077216, Mar 29, 2012
Filed:

Jun 16, 2010
Appl. No.:

13/375189
Inventors:

Xiyun Zhang - Fremont CA, US
Jie Yang - Foster City CA, US
Dipnath Baidyaroy - Fremont CA, US
Sally Rhiannon Postlethwaite - Redwood City CA, US
Attila Andor - Budapest, HU
Louis Clark - San Francisco CA, US
Lisa M. Newman - San Jose CA, US
Assignee:

Codexis, Inc. - Redwood City CA
International Classification:

C12Q 1/34
C12N 9/42
US Classification:

435 18, 435209
Abstract:

The invention relates to recombinantly produced β-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

Multi-Cellulase Enzyme Compositions For Hydrolysis Of Cellulosic Biomass
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US Patent:

20120231510, Sep 13, 2012
Filed:

Nov 18, 2010
Appl. No.:

13/508691
Inventors:

Kripa Rao - San Mateo CA, US
Ish Dhawan - Foster City CA, US
Sally Postlethwaite - Redwood City CA, US
Jie Yang - Foster City CA, US
Assignee:

Codexis, Inc. - Redwood City CA
International Classification:

C12N 9/42
C12P 7/14
C12P 7/18
C12P 13/04
C12P 5/02
C12P 19/14
C12P 7/40
US Classification:

435 99, 435209, 435162, 435136, 435106, 435167, 435158
Abstract:

The invention relates to a multi-cellulase enzyme composition for the enzymatic hydrolysis of cellulosic biomass said composition comprising a cellobiohydrolase (CBH) enzyme, an endoglucanase (EG) enzyme and a β-glucosidase (BG) enzyme.

Compositions, Formulations And Interleukin Production And Purification
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US Patent:

20210154304, May 27, 2021
Filed:

Feb 5, 2021
Appl. No.:

17/169390
Inventors:

- South San Francisco CA, US
Randall J. Mrsny - Los Altos Hills CA, US
Kevin Yin - Palo Alto CA, US
Tahir Mahmood - Burlingame CA, US
Bittoo Kanwar - San Francisco CA, US
Sally Postlethwaite - Redwood City CA, US
Weijun Feng - Danville CA, US
Sean Dalziel - South San Francisco CA, US
Hyojin Kim - San Carlos CA, US
Rajendra Tandale - Atwater CA, US
Marvin Garovoy - Sausalito CA, US
John Koleng - Austin TX, US
International Classification:

A61K 47/34
C07K 14/54
A61K 47/38
A61K 47/32
Abstract:

Described herein are cholix-IL-10 fusion proteins, and methods of use thereof, which can be characterized by a distinct response in an individual when administered. This distinct response can comprise changes in levels of one or more markers in the individual and/or co-localization of IL-10 in the lamina propria of the individual. Further described herein, in some embodiments, are oral formulations of the cholix-IL-10 fusion proteins. Described herein are methods for the purification of an IL-10 delivery construct, including methods for refolding and enrichment, which can result in maintenance of a high percentage of the IL-10 delivery constructs in the biologically active dimer form. Described herein are oral formulations configured for site-specific release of a therapeutic protein in the small intestines or colon. In some cases, the therapeutic protein is in the form of a dimer, such as an IL-10 delivery construct capable of crossing the gut epithelium.

Cholix-Derived Carriers For Oral Delivery Of Heterologous Payload
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US Patent:

20210100911, Apr 8, 2021
Filed:

May 27, 2020
Appl. No.:

16/884456
Inventors:

- South San Francisco CA, US
Charles Olson - South San Francisco CA, US
Derek Maclean - Los Altos CA, US
Sally Postlethwaite - Redwood City CA, US
Amir Porat - Belmont CA, US
International Classification:

A61K 47/64
C07K 14/195
Abstract:

The present disclosure provides delivery constructs comprising a carrier coupled to a heterologous payload, wherein coupling of the carrier to the payload can result in transportation of the payload (e.g., a therapeutic payload) into and/or across intact polarized epithelial cells (e.g., epithelial cells of the gut of a mammal). The delivery construct can be part of a pharmaceutical composition that can be orally administered to a subject to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases or autoimmune diseases.

Beta-Glucosidase Variants
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US Patent:

20150064766, Mar 5, 2015
Filed:

Nov 13, 2014
Appl. No.:

14/540422
Inventors:

- REDWOOD CITY CA, US
Jie Yang - Foster City CA, US
Dipnath Baidyaroy - Fremont CA, US
Sally R. Postlethwaite - Redwood City CA, US
Attila Andor - Budapest, HU
Louis A. Clark - San Francisco CA, US
Lisa Marie Newman - San Jose CA, US
International Classification:

C12N 9/42
US Classification:

435209
Abstract:

The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

Beta-Glucosidase Variants
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US Patent:

20140256018, Sep 11, 2014
Filed:

May 28, 2014
Appl. No.:

14/289021
Inventors:

- Redwood City CA, US
Jie Yang - Foster City CA, US
Dipnath Baidyaroy - Fremont CA, US
Sally R. Postlethwaite - Redwood City CA, US
Attila Andor - Budapest, HU
Louis A. Clark - San Francisco CA, US
Lisa Marie Newman - San Jose CA, US
Assignee:

Codexis, Inc. - Redwood City CA
International Classification:

C12N 9/24
US Classification:

435200
Abstract:

The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

Sally R Postlethwaite

Sally Postlethwaite Phones & Addresses

Work

Education

Skills

Industries

Resumes

Principal Scientist

Us Patents

Beta-Glucosidase Variant Enzymes And Related Polynucleotides

Beta-Glucosidase Variants

Multi-Cellulase Enzyme Compositions For Hydrolysis Of Cellulosic Biomass

Compositions, Formulations And Interleukin Production And Purification

Cholix-Derived Carriers For Oral Delivery Of Heterologous Payload

Beta-Glucosidase Variants

Beta-Glucosidase Variants