Sam S Hwang

US Patent:

20040132642, Jul 8, 2004

Filed:

Nov 12, 2003

Appl. No.:

10/706265

Inventors:

Sam Hwang - Potomac MD, US

Assignee:

Government of the U.S.A., represented by the Secretary, Dept. of Health & Human Services - Rockville MD

International Classification:

A61K038/12

US Classification:

514/009000, 514/010000

Abstract:

Methods of inhibiting metastasis of a CXCR4-expressing tumor cell in a mammal, which methods comprise administering to the mammal in an amount sufficient to inhibit metastasis of the tumor cell an antagonist of CXCR4, such as a polypeptide of the formula described herein, an antagonist of integrin, such as an antibody that binds to , an antagonist of CXCL12, such as an antibody that binds to CXCL12, or an antagonist of integrin, such as an antibody that binds to ; and a method of inhibiting growth of a CXCR4 expressing-tumor cell in a mammal, which method comprises administering to the tumor cell a polypeptide of the formula described herein.