Samantha N Seidor

US Patent:

20130150810, Jun 13, 2013

Filed:

Feb 5, 2013

Appl. No.:

13/759981

Inventors:

Mitchell Thorn - Astoria NY, US
David M. Phillips - Piermont NY, US
Naomi Rutenberg - Washington DC, US
Thomas M. Zydowsky - Brooklyn NY, US
Shweta Ugaonkar - Elmhurst NY, US
Samantha Seidor - New York NY, US

Assignee:

THE POPULATION COUNCIL, INC. - New York NY

International Classification:

A61M 31/00

US Classification:

604285, 427 21

Abstract:

Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions. Also disclosed are intravaginal rings for delivering water-soluble compounds, and preferably high molecular weight water-soluble polymers at essentially a zero order rate. The rings include an outer layer of non-water-swellable elastomer, and preferably high molecular weight water-soluble polymer and an inner layer of the water-soluble polymer, which is imbedded in the outer layer, and an aperture through the outer layer for release thereof only through that aperture.