Sameer S Sule

US Patent:

58558950, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/478552

Inventors:

Alexander K. Andrianov - Belmont MA
Lendon G. Payne - Arlington MA
Jonathan R. Sargent - Somerville MA
Sameer S. Sule - Woburn MA

Assignee:

Virus Research Institute - Cambridge MA

International Classification:

A61K 3939
A61K 4500
A61K 4505

US Classification:

4242801

Abstract:

A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.

US Patent:

58690166, Feb 9, 1999

Filed:

Jun 18, 1997

Appl. No.:

8/877823

Inventors:

Alexander K. Andrianov - Belmont MA
Mark P. LeGolvan - West Roxbury MA
Yuri Svirkin - Belmont MA
Sameer S. Sule - Marlboro MA

Assignee:

Virus Research Institute, Inc. - Cambridge MA

International Classification:

C01B 2510

US Classification:

423300

Abstract:

A method for producing a polyorganophosphazene, such as, for example, poly�di(carboxylatophenoxy)phosphazenel!, from polydichlorophosphazene. The polydichlorophosphazene is reacted with at least one nucleophilic reagent at a defined molar ratio of the at least one nucleophilic reagent to the polydichlorophosphazene. Such process results in the production of a polyorganophosphazene having a molecular weight within a desired range.

US Patent:

60155639, Jan 18, 2000

Filed:

Nov 4, 1998

Appl. No.:

9/185834

Inventors:

Alexander K. Andrianov - Belmont MA
Lendon G. Payne - Arlington MA
Jonathan R. Sargent - Somerville MA
Sameer S. Sule - Woburn MA

Assignee:

AVANT Immunotherapeutics, Inc. - Needham MA

International Classification:

A61K 3900
A61K 4500
A61K 5100

US Classification:

4241841

Abstract:

A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.

US Patent:

57075972, Jan 13, 1998

Filed:

Nov 13, 1996

Appl. No.:

8/747613

Inventors:

Alexander K. Andrianov - Belmont MA
Jonathan R. Sargent - Santa Monica CA
Sameer S. Sule - Marlboro MA
Mark LeGolvan - West Roxbury MA

Assignee:

Virus Research Institute, Inc. - Cambridge MA

International Classification:

C01B 2510
C08L 8502

US Classification:

423265

Abstract:

A solution which comprises a polyphosphazene solute, such as a polyhalophosphazene solute, and a stabilizing solvent such as diglyme. Such solution enables the polyphosphazene to remain stable for extended periods of time so that such polyhalophosphazenes may be employed for further modification or use.

US Patent:

58147047, Sep 29, 1998

Filed:

Mar 4, 1997

Appl. No.:

8/810728

Inventors:

Alexander K. Andrianov - Belmont MA
Jonathan R. Sargent - Los Angeles CA
Sameer S. Sule - Marlboro MA

Assignee:

Virus Research Institute, Inc. - Cambridge MA

International Classification:

C08L 4302

US Classification:

525209

Abstract:

A process for recovering a polyphosphazene polyacid or acid salt obtained by hydrolyzing a polyphosphazene having at least one ester moiety present in at least one substituent group. The polyphosphazene having at least one ester moiety present in at least one substituent group is hydrolyzed with a base in an organic solvent in the presence of water. The water is present in an amount effective to induce the agglomeration of particles of the synthesized polyphosphazene polyacid or acid salt, which enhances the separation of the polyphosphazene polyacid or acid salt from a polymer-free liquid organic phase. The polymer-free liquid organic phase then is separated from the polyphosphazene acid or acid salt, whereby the polyphosphazene acid or acid salt is recovered.

US Patent:

58424717, Dec 1, 1998

Filed:

May 14, 1997

Appl. No.:

8/856073

Inventors:

Alexander K. Andrianov - Belmont MA
Mark P. LeGolvan - West Roxbury MA
Yuri Svirkin - Belmont MA
Sameer S. Sule - Marlboro MA

Assignee:

Virus Research Institute, Inc. - Cambridge MA

International Classification:

C08G 7902

US Classification:

528398

Abstract:

A method for purification of a polyphosphazene polyacid or acid salt thereof in which a polyphosphazene polyacid or acid salt thereof is dissolved in a concentrated aqueous solution of a salt of monovalent ions. The resulting aqueous solution of the polyphosphazene polyacid or acid salt thereof and the at least one salt of monovalent ions then is diluted to reduce the concentration of the at least one salt of monovalent ions, whereby the polyphosphazene polyacid or acid salt thereof is precipitated. The precipitated polyphosphazene polyacid or acid salt thereof then is recovered.