Samuel J Epstein

US Patent:

6923996, Aug 2, 2005

Filed:

May 6, 2003

Appl. No.:

10/430165

Inventors:

Samuel J. Epstein - Newton MA, US
Wendy Naimark - Cambridge MA, US

Assignee:

SciMed Life Systems, Inc. - Maple Grove MN

International Classification:

B05D003/00

US Classification:

427 224, 427 226, 427 228, 427 23, 4274071, 427409, 427413, 427421

Abstract:

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

US Patent:

7070582, Jul 4, 2006

Filed:

Aug 9, 2002

Appl. No.:

10/215034

Inventors:

Toby Freyman - Watertown MA, US
Wendy Naimark - Cambridge MA, US
Tim Mickley - Elk River MN, US
Samuel J. Epstein - Newton MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/32

US Classification:

604272, 604239, 604176, 604119, 604121

Abstract:

Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.

US Patent:

7169127, Jan 30, 2007

Filed:

Feb 21, 2002

Appl. No.:

10/078676

Inventors:

Samuel J. Epstein - Lynnfield MA, US
Wendy Naimark - Cambridge MA, US
Tim Mickley - Elk River MN, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/00

US Classification:

604117, 604264, 604180

Abstract:

A pressure apron for insitu plug formation is provided. In one embodiment an injection tube having a first channel and a piercing tip is provided, the first channel in fluid communication with a pressure source. In this embodiment, the injection catheter may also include a pressure apron with a tissue-mating surface. In another embodiment a medical kit for delivering a therapeutic is provided. This medical kit may include a catheter having a channel and a piercing tip, the piercing tip in fluid communication with a pressure source and slidably placed in the channel. The catheter in this embodiment may include a pressure apron with a tissue-mating source while a therapeutic may be included with the kit.

US Patent:

7390525, Jun 24, 2008

Filed:

Jan 12, 2005

Appl. No.:

11/033918

Inventors:

Samuel J. Epstein - Newton MA, US
Wendy Naimark - Cambridge MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

B05D 3/00

US Classification:

427 224, 427 226, 427 228, 427 23, 4274071, 427409, 427413, 427421

Abstract:

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Moreover, in certain embodiments, the polymer-containing layer does not comprise the cross-linking agent at the time the polymer-containing layer is applied over the reactive layer. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

US Patent:

7803141, Sep 28, 2010

Filed:

Aug 12, 2003

Appl. No.:

10/638426

Inventors:

Samuel J. Epstein - Watertown MA, US
Wendy Naimark - Cambridge MA, US
Toby Freyman - Waltham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/00

US Classification:

604264, 604 9301

Abstract:

A device, system, and method for direct delivery of a therapeutic to a target site that utilizes the non-Newtonian characteristics of shear thinning and shear thickening to allow easy passage of a therapeutic through a delivery lumen yet facilitate retention of the therapeutic in the target site. The device, system, and method includes increasing the shear rate or shear stress of a non-Newtonian fluid having therapeutic properties thereby increasing or decreasing the viscosity of the non-Newtonian fluid.

US Patent:

7892205, Feb 22, 2011

Filed:

Jun 6, 2003

Appl. No.:

10/455298

Inventors:

Maria Palasis - Wellesley MA, US
Wendy Naimark - Cambridge MA, US
Toby Freyman - Waltham MA, US
Samuel Epstein - Watertown MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 37/00

US Classification:

604147, 604149, 604246

Abstract:

The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

US Patent:

7938799, May 10, 2011

Filed:

Jul 20, 2007

Appl. No.:

11/780885

Inventors:

Samuel J. Epstein - Watertown MA, US
Toby Freyman - Waltham MA, US
Chad G. Harris - Albertville MN, US
Timothy J. Mickley - Elk River MN, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 31/00
A61M 37/00

US Classification:

60410303

Abstract:

The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

US Patent:

8235937, Aug 7, 2012

Filed:

Feb 7, 2011

Appl. No.:

13/022217

Inventors:

Maria Palasis - Wellesley MA, US
Wendy Naimark - Boston MA, US
Toby Freyman - Waltham MA, US
Samuel Epstein - Marlborough MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 31/00

US Classification:

604 60, 604140, 604147, 604246

Abstract:

The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.