Samuel H Epstein

US Patent:

6923996, Aug 2, 2005

Filed:

May 6, 2003

Appl. No.:

10/430165

Inventors:

Samuel J. Epstein - Newton MA, US
Wendy Naimark - Cambridge MA, US

Assignee:

SciMed Life Systems, Inc. - Maple Grove MN

International Classification:

B05D003/00

US Classification:

427 224, 427 226, 427 228, 427 23, 4274071, 427409, 427413, 427421

Abstract:

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

US Patent:

7070582, Jul 4, 2006

Filed:

Aug 9, 2002

Appl. No.:

10/215034

Inventors:

Toby Freyman - Watertown MA, US
Wendy Naimark - Cambridge MA, US
Tim Mickley - Elk River MN, US
Samuel J. Epstein - Newton MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/32

US Classification:

604272, 604239, 604176, 604119, 604121

Abstract:

Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.

US Patent:

7169127, Jan 30, 2007

Filed:

Feb 21, 2002

Appl. No.:

10/078676

Inventors:

Samuel J. Epstein - Lynnfield MA, US
Wendy Naimark - Cambridge MA, US
Tim Mickley - Elk River MN, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/00

US Classification:

604117, 604264, 604180

Abstract:

A pressure apron for insitu plug formation is provided. In one embodiment an injection tube having a first channel and a piercing tip is provided, the first channel in fluid communication with a pressure source. In this embodiment, the injection catheter may also include a pressure apron with a tissue-mating surface. In another embodiment a medical kit for delivering a therapeutic is provided. This medical kit may include a catheter having a channel and a piercing tip, the piercing tip in fluid communication with a pressure source and slidably placed in the channel. The catheter in this embodiment may include a pressure apron with a tissue-mating source while a therapeutic may be included with the kit.

US Patent:

7390525, Jun 24, 2008

Filed:

Jan 12, 2005

Appl. No.:

11/033918

Inventors:

Samuel J. Epstein - Newton MA, US
Wendy Naimark - Cambridge MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

B05D 3/00

US Classification:

427 224, 427 226, 427 228, 427 23, 4274071, 427409, 427413, 427421

Abstract:

A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Moreover, in certain embodiments, the polymer-containing layer does not comprise the cross-linking agent at the time the polymer-containing layer is applied over the reactive layer. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

US Patent:

7409635, Aug 5, 2008

Filed:

Nov 16, 2005

Appl. No.:

11/281780

Inventors:

Samuel S. Epstein - Sammamish WA, US

Assignee:

Zalag Corporation - Sammamish WA

International Classification:

G06F 17/00

US Classification:

715243

Abstract:

Methods and apparatuses for generating rendering layout specifications for content items to be rendered, using display containers, and/or rendering the content items using the generated rendering layout specification are disclosed. In various embodiments, the generating of a rendering layout specification may include one or more of selecting a display container for a content item, selecting a content item for a display container, and selecting a display container for a display container.

US Patent:

7765470, Jul 27, 2010

Filed:

Jul 25, 2008

Appl. No.:

12/179860

Inventors:

Samuel S. Epstein - Sammamish WA, US

Assignee:

Zalag Corporation - Sammamish WA

International Classification:

G07F 17/00

US Classification:

715243, 715253

Abstract:

Methods and apparatuses for generating rendering layout specifications for content items to be rendered, using display containers, and/or rendering the content items using the generated rendering layout specification are disclosed. In various embodiments, the generating of a rendering layout specification may include one or more of selecting a display container for a content item, selecting a content item for a display container, and selecting a display container for a display container.

US Patent:

7803141, Sep 28, 2010

Filed:

Aug 12, 2003

Appl. No.:

10/638426

Inventors:

Samuel J. Epstein - Watertown MA, US
Wendy Naimark - Cambridge MA, US
Toby Freyman - Waltham MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 5/00

US Classification:

604264, 604 9301

Abstract:

A device, system, and method for direct delivery of a therapeutic to a target site that utilizes the non-Newtonian characteristics of shear thinning and shear thickening to allow easy passage of a therapeutic through a delivery lumen yet facilitate retention of the therapeutic in the target site. The device, system, and method includes increasing the shear rate or shear stress of a non-Newtonian fluid having therapeutic properties thereby increasing or decreasing the viscosity of the non-Newtonian fluid.

US Patent:

7892205, Feb 22, 2011

Filed:

Jun 6, 2003

Appl. No.:

10/455298

Inventors:

Maria Palasis - Wellesley MA, US
Wendy Naimark - Cambridge MA, US
Toby Freyman - Waltham MA, US
Samuel Epstein - Watertown MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 37/00

US Classification:

604147, 604149, 604246

Abstract:

The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.