S. Jane deSolms - Norristown PA Samuel L. Graham - Schwenksville PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3147
US Classification:
514307, 514419, 546147, 548492
Abstract:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.
Christopher J. Dinsmore - Schwenksville PA Jeffrey M. Bergman - Perkasie PA Samuel L. Graham - Schwenksville PA Diem N. Nguyen - North Wales PA Gerald E. Stokker - Gwynedd Valley PA Theresa M. Williams - Harleysville PA C. Blair Zartman - Hatfield PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C07D26700
US Classification:
514250, 540469
Abstract:
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
Stanley F. Barnett - North Wales PA, US Samuel L. Graham - Schwenksville PA, US David C. Remy - North Wales PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/498 C07D 241/42
US Classification:
514249, 544353
Abstract:
The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Ian M. Bell - Harleysville PA, US Samuel L. Graham - Schwenksville PA, US Theresa M. Williams - Harleysville PA, US Craig A. Stump - Pottstown PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 403/12 A61K 31/55 A61P 25/06
US Classification:
514221, 540509
Abstract:
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Bicyclic Spiropiperidine Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
Ivory D. Hills - Harleysville PA, US Craig A. Coburn - Royersford PA, US Samuel L. Graham - Schwenksville PA, US Keith P. Moore - Harleysville PA, US Philippe G. Nantermet - Lansdale PA, US Hemaka A. Rajapakse - Wyncote PA, US Shawn J. Stachel - Perkasie PA, US Hong Zhu - Lansdale PA, US
Daniel V. Paone - Lansdale PA, US Diem N. Nguyen - Harleysville PA, US Anthony W. Shaw - Harleysville PA, US Christopher S. Burgey - Philadelphia PA, US Thomas J. Tucker - North Wales PA, US Samuel L. Graham - Schwenksville PA, US
S. deSolms - Norristown PA, US Samuel Graham - Schwenksville PA, US Anthony Shaw - Lansdale PA, US Terrence Ciccarone - Telford PA, US Gerald Stokker - Gwynedd Valley PA, US
The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
Octagon Credit Investors since Jul 2013
Analyst
BlackRock - Greater Seattle Area Jun 2012 - Aug 2012
Analyst Intern
Steelhead Partners LLC - Bellevue, WA May 2011 - Aug 2011
Analyst Intern
Strategic Capital Group May 2010 - Aug 2010
Intern
Education:
University of Pennsylvania - The Wharton School 2009 - 2013
B.S., Finance, General
Woodinville
Interests:
Investing, traveling, football, basketball, the outdoors
Woodward Ave Royal Oak, MI 48067Schulman & Associates, P.C. specializes in criminal defense and family law matters and has attorneys who also specialize in personal injury, workers... Schulman & Associates, P.C. specializes in criminal defense and family law matters and has attorneys who also specialize in personal injury, workers compensation, civil litigation, immigration, bankruptcy, probate, wills, estates, trusts, and literally all types of legal matters.
If you have been...