Samuel E Graham

US Patent:

6989383, Jan 24, 2006

Filed:

Jun 4, 1998

Appl. No.:

09/445054

Inventors:

Neal Rosen - Englewood NJ, US
Laura Sepp-Lorenzino - New Haven CT, US
Mark M. Moasser - New York NY, US
Allen I. Oliff - Gwynedd Valley PA, US
Jackson B. Gibbs - Chalfont PA, US
Nancy Kohl - Wyndmoor PA, US
Samuel L. Graham - Schwenksville PA, US
George C. Prendergast - Bala Cynwyd PA, US

Assignee:

Sloan-Kettering Institute For Cancer Research - New York NY

International Classification:

A61K 31/495
A61K 31/50
A61K 31/335
A61K 31/35
A61K 31/34

US Classification:

51425405, 51425501, 51425502, 514449, 514459, 514471, 514616

Abstract:

The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at lest two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is an inhibitor or prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

US Patent:

20050137207, Jun 23, 2005

Filed:

Feb 15, 2005

Appl. No.:

11/059084

Inventors:

Neal Rosen - Englewood NJ, US
Laura Sepp-Lorenzino - Landsdale PA, US
Mark Moasser - San Francisco CA, US
Allen Oliff - Gwynedd Valley PA, US
Jackson Gibbs - Chalfont PA, US
Nancy Kohl - Wellesley MA, US
Samuel Graham - Schwenksville PA, US
George Prendergast - Bala-Cynwyd PA, US

International Classification:

A61K031/496
A61K031/495

US Classification:

514253010, 514255010, 514254050

Abstract:

The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.