Samuel C Graham

US Patent:

6500841, Dec 31, 2002

Filed:

Sep 12, 1996

Appl. No.:

08/716260

Inventors:

S. Jane deSolms - Norristown PA
Samuel L. Graham - Schwenksville PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3147

US Classification:

514307, 514419, 546147, 548492

Abstract:

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.

US Patent:

6562823, May 13, 2003

Filed:

Jun 28, 2001

Appl. No.:

09/719878

Inventors:

Christopher J. Dinsmore - Schwenksville PA
Jeffrey M. Bergman - Perkasie PA
Samuel L. Graham - Schwenksville PA
Diem N. Nguyen - North Wales PA
Gerald E. Stokker - Gwynedd Valley PA
Theresa M. Williams - Harleysville PA
C. Blair Zartman - Hatfield PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D26700

US Classification:

514250, 540469

Abstract:

The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

US Patent:

6989383, Jan 24, 2006

Filed:

Jun 4, 1998

Appl. No.:

09/445054

Inventors:

Neal Rosen - Englewood NJ, US
Laura Sepp-Lorenzino - New Haven CT, US
Mark M. Moasser - New York NY, US
Allen I. Oliff - Gwynedd Valley PA, US
Jackson B. Gibbs - Chalfont PA, US
Nancy Kohl - Wyndmoor PA, US
Samuel L. Graham - Schwenksville PA, US
George C. Prendergast - Bala Cynwyd PA, US

Assignee:

Sloan-Kettering Institute For Cancer Research - New York NY

International Classification:

A61K 31/495
A61K 31/50
A61K 31/335
A61K 31/35
A61K 31/34

US Classification:

51425405, 51425501, 51425502, 514449, 514459, 514471, 514616

Abstract:

The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at lest two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is an inhibitor or prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

US Patent:

7034026, Apr 25, 2006

Filed:

Apr 8, 2002

Appl. No.:

10/473788

Inventors:

Stanley F. Barnett - North Wales PA, US
Samuel L. Graham - Schwenksville PA, US
David C. Remy - North Wales PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/498
C07D 241/42

US Classification:

514249, 544353

Abstract:

The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

US Patent:

7205293, Apr 17, 2007

Filed:

Mar 10, 2004

Appl. No.:

10/547228

Inventors:

Ian M. Bell - Harleysville PA, US
Samuel L. Graham - Schwenksville PA, US
Theresa M. Williams - Harleysville PA, US
Craig A. Stump - Pottstown PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 403/12
A61K 31/55
A61P 25/06

US Classification:

514221, 540509

Abstract:

The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

US Patent:

8377954, Feb 19, 2013

Filed:

Dec 28, 2007

Appl. No.:

12/522056

Inventors:

Shaun R. Stauffer - Schwenksville PA, US
Samuel L. Graham - Schwenksville PA, US

Assignee:

Merck, Sharp & Dohme, Corp - Rahway NJ

International Classification:

C07D 401/14
A61K 31/438

US Classification:

514278, 546 17, 546 20

Abstract:

The present invention is directed to bicyclic spiropiperidine compounds of formula (I).

US Patent:

8492387, Jul 23, 2013

Filed:

Feb 18, 2009

Appl. No.:

12/919277

Inventors:

Ivory D. Hills - Harleysville PA, US
Craig A. Coburn - Royersford PA, US
Samuel L. Graham - Schwenksville PA, US
Keith P. Moore - Harleysville PA, US
Philippe G. Nantermet - Lansdale PA, US
Hemaka A. Rajapakse - Wyncote PA, US
Shawn J. Stachel - Perkasie PA, US
Hong Zhu - Lansdale PA, US

Assignee:

Merck, Sharp & Dohme, Corp. - Rahway NJ

International Classification:

A61K 31/506
A61K 31/42
A61K 31/4174
A61K 31/4178
A61K 31/4439
A61K 31/422
C07D 233/88
C07D 403/10
C07D 403/06
C07D 413/10
C07D 401/10

US Classification:

514256, 514341, 514374, 514378, 514397, 514398, 544333, 5462714, 5462727, 548247, 5483144, 5483151, 5483265, 548 6

Abstract:

The present invention is directed to 2-aminoimidazole compounds of formula (I).

US Patent:

7994325, Aug 9, 2011

Filed:

Mar 14, 2006

Appl. No.:

11/885926

Inventors:

Daniel V. Paone - Lansdale PA, US
Diem N. Nguyen - Harleysville PA, US
Anthony W. Shaw - Harleysville PA, US
Christopher S. Burgey - Philadelphia PA, US
Thomas J. Tucker - North Wales PA, US
Samuel L. Graham - Schwenksville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/444
C07D 211/86

US Classification:

546193, 546198, 546199, 514318

Abstract:

Compounds of Formula I:.