Samuel I Martin

US Patent:

7008774, Mar 7, 2006

Filed:

Jun 18, 2002

Appl. No.:

10/173586

Inventors:

Jeffrey R. Ryan - Reston VA, US
Samuel K. Martin - Burtonsville MD, US
Anthony M. Smithyman - Collaroy, AU

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

G01N 33/53
C12Q 1/70
C12Q 1/69
A61K 30/005
C07K 14/00

US Classification:

435 71, 435 5, 435 6, 435 722, 4242691, 424 931, 530350

Abstract:

Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to parasite soluble antigens and antigen-capture ELISAs for the detection of parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of amastigotes or promastigotes in a sample.

US Patent:

7566465, Jul 28, 2009

Filed:

Dec 21, 2006

Appl. No.:

11/644494

Inventors:

Bruno K. Kubata - Nairobi, KE
Samuel K. Martin - Burtonsville MD, US
Wilbur K. Milhous - Germantown MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 36/282

US Classification:

424740

Abstract:

The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.

US Patent:

20020064801, May 30, 2002

Filed:

Nov 29, 2000

Appl. No.:

09/725182

Inventors:

Jeffrey Ryan - Reston VA, US
Samuel Martin - Burtonsville MD, US
Anthony Smithyman - Collaroy NSW, AU

International Classification:

G01N033/53
G01N033/569

US Classification:

435/007300

Abstract:

Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.

US Patent:

20050208600, Sep 22, 2005

Filed:

Nov 18, 2004

Appl. No.:

10/990971

Inventors:

Samuel Martin - Burtonsville MD, US

International Classification:

G01N033/53
G01N033/569

US Classification:

435007220

Abstract:

Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.

US Patent:

20090317499, Dec 24, 2009

Filed:

Jul 16, 2009

Appl. No.:

12/460289

Inventors:

Bruno K. Kubata - Nairobi, KE
Samuel K. Martin - Burtonsville MD, US
Wilbur K. Milhous - Germantown MD, US

International Classification:

A61K 36/282
A61K 31/335
A61P 33/00

US Classification:

424740, 514450

Abstract:

The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant . The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.

US Patent:

48974030, Jan 30, 1990

Filed:

Nov 18, 1986

Appl. No.:

6/936677

Inventors:

Samuel K. Martin - Silver Spring MD
Ayo M. J. Oduola - Gaithersburg MD
Wilbur K. Milhous - Rockville MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 3147
A61K 31275
A61K 3144

US Classification:

514313

Abstract:

An antimalarial composition contains as the active ingredient a mixture of chemical compound effective in reversing the resistance of cancer cells to chemotherapy drugs and at least one antimalarial agent. A method for treating malaria in mammals comprises administering a composition containing the active ingredient. A method for reducing the resistance of a malarial parasite to an antimalarial agent comprises administering a composition containing the active ingredient.

US Patent:

20140243402, Aug 28, 2014

Filed:

Feb 4, 2014

Appl. No.:

13/999318

Inventors:

Bruno K. Kubata - Nairobi, KE
Samuel K. Martin - Burtonsville MD, US
Wilbur K. Milhous - Germantown MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Fort Detrick MD

International Classification:

A61K 31/366
A61K 36/282

US Classification:

514450

Abstract:

The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant . The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.